Summary: Glucosidase II beta subunit-like protein
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Glucosidase II beta subunit-like protein Provide feedback
The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II (P14314), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing . The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum . The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit .
Pelletier MF, Marcil A, Sevigny G, Jakob CA, Tessier DC, Chevet E, Menard R, Bergeron JJ, Thomas DY; , Glycobiology 2000;10:815-827.: The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. PUBMED:10929008 EPMC:10929008
Watanabe T, Totani K, Matsuo I, Maruyama J, Kitamoto K, Ito Y;, Glycobiology. 2009;19:834-840.: Genetic analysis of glucosidase II beta-subunit in trimming of high-mannose-type glycans. PUBMED:19395677 EPMC:19395677
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This tab holds annotation information from the InterPro database.
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Curation and family details
|Seed source:||Wood V|
|Number in seed:||5|
|Number in full:||752|
|Average length of the domain:||148.40 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||29.04 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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