Summary: Phosphotransferase system, EIIC
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Phosphotransferase system, EIIC Provide feedback
The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyses the transfer of a phosphoryl group from IIB to the sugar substrate.
Reizer J, Paulsen IT, Reizer A, Titgemeyer F, Saier MH Jr; , Microb Comp Genomics 1996;1:151-164.: Novel phosphotransferase system genes revealed by bacterial genome analysis: the complete complement of pts genes in mycoplasma genitalium. PUBMED:9689210 EPMC:9689210
Internal database links
|Similarity to PfamA using HHSearch:||PTS_EIIC_2|
External database links
|Transporter classification:||4.A.2 4.A.1 4.A.3|
This tab holds annotation information from the InterPro database.
InterPro entry IPR003352The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The general mechanism of the PTS is the following: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred to enzyme-I (EI) of PTS which in turn transfers it to a phosphoryl carrier protein (HPr). Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease which consists of at least three structurally distinct domains (IIA, IIB, and IIC) [PUBMED:1537788] which can either be fused together in a single polypeptide chain or exist as two or three interactive chains, formerly called enzymes II (EII) and III (EIII). The IIC domain catalyzes the transfer of a phosphoryl group from IIB to the sugar substrate.
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|Cellular component||membrane (GO:0016020)|
|Molecular function||sugar:hydrogen symporter activity (GO:0005351)|
|protein-N(PI)-phosphohistidine-sugar phosphotransferase activity (GO:0008982)|
|Biological process||phosphoenolpyruvate-dependent sugar phosphotransferase system (GO:0009401)|
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Curation and family details
|Seed source:||Pfam-B_639 (release 5.2)|
|Author:||Mian N, Bateman A|
|Number in seed:||55|
|Number in full:||25880|
|Average length of the domain:||300.10 aa|
|Average identity of full alignment:||17 %|
|Average coverage of the sequence by the domain:||57.49 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||13|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PTS_EIIC domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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