Summary: Mitochondrial import protein Pam17
Mitochondrial import protein Pam17 Provide feedback
The presequence translocase-associated motor (PAM) drives the completion of preprotein translocation into the mitochondrial matrix. The Pam17 subunit is required for formation of a stable complex between cochaperones Pam16 and Pam18 and promotes the association of Pam16-Pam18 with the presequence translocase . Mitochondria lacking Pam17 are selectively impaired in the import of matrix proteins .
van der Laan M, Chacinska A, Lind M, Perschil I, Sickmann A, Meyer HE, Guiard B, Meisinger C, Pfanner N, Rehling P; , Mol Cell Biol. 2005;25:7449-7458.: Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor. PUBMED:16107694 EPMC:16107694
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013875
The presequence translocase-associated motor (PAM) drives the completion of preprotein translocation into the mitochondrial matrix. The Pam17 subunit is required for formation of a stable complex between cochaperones Pam16 and Pam18 and promotes the association of Pam16-Pam18 with the presequence translocase [PUBMED:16107694]. Mitochondria lacking Pam17 are selectively impaired in the import of matrix proteins [PUBMED:16107694].
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This clan contains membrane proteins involved in the transport of molecules including amino acids sugars and signalling molecules. It also includes integral membrane cell cycle proteins and some putative ammonia monooxygenases.
The clan contains the following 6 members:ABC-3 AmoA BPD_transp_2 FecCD FTSW_RODA_SPOVE Pam17
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Author:||Mistry J, Wood V|
|Number in seed:||24|
|Number in full:||137|
|Average length of the domain:||173.70 aa|
|Average identity of full alignment:||40 %|
|Average coverage of the sequence by the domain:||77.72 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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