Summary: ParB-like nuclease domain
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ParB-like nuclease domain Provide feedback
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Internal database links
|Similarity to PfamA using HHSearch:||ParBc_2|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003115
Proteins containing this domain include Escherichia coli plasmid protein ParB and mammalian Sulfiredoxin-1.
ParB is involved in chromosome partition. It localize to both poles of the predivisional cell following completion of DNA replication [PUBMED:12603730].
Sulfiredoxin-1 contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 [PUBMED:15448164].
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This example describes an architecture with one
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Alignment kindly provided by SMART|
|Number in seed:||36|
|Number in full:||9891|
|Average length of the domain:||91.20 aa|
|Average identity of full alignment:||28 %|
|Average coverage of the sequence by the domain:||27.08 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||17|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ParBc domain has been found. There are 33 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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