Summary: Peptidase C80 family
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Peptidase C80 family Provide feedback
This family belongs to cysteine peptidase family C80.
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR020974
This entry identifies a domain that functions as a cysteine peptidase that belongs to MEROPS peptidase family C80 (RTX self-cleaving toxin, clan CD).
This domain is found in bacterial toxins that self-process by a cysteine peptidase mechanism. These include Vibrio cholerae RTX toxin [PUBMED:17464284], and Clostridium difficile toxins A and B [PUBMED:17591770]. Some pathogenic bacteria produce unrelated toxins that also require activation and processing, the processing often being autolytic as it is in anthrax lethal factor, tentoxilysin (the tetanus neurotoxin) and bontoxilysin (the botulinum neurotoxin), all of which are metallopeptidases.
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
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The members of this clan are all endopeptidase that have the catalytic dyad histidine followed by cysteine. The catalytic histidine is preceded by a block of hydrophobic residues and a glycine, where as the cysteine is preceded by a block of hydrophobic residues and a glutamine and an alanine. The members with a know structure adopt an alpha/beta fold .
The clan contains the following 9 members:CHAT GVQW Peptidase_C11 Peptidase_C13 Peptidase_C14 Peptidase_C25 Peptidase_C50 Peptidase_C80 Raptor_N
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Rawlings ND|
|Author:||Rawlings ND, Bateman A|
|Number in seed:||13|
|Number in full:||1136|
|Average length of the domain:||164.10 aa|
|Average identity of full alignment:||34 %|
|Average coverage of the sequence by the domain:||7.73 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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The tree shows the occurrence of this domain across different species. More...
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Peptidase_C80 domain has been found. There are 14 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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