Summary: Pestivirus NS3 polyprotein peptidase S31
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Pestivirus NS3 polyprotein peptidase S31 Provide feedback
These serine peptidases are involved in processing of the flavivirus polyprotein.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000280
The genome of pestiviruses is a single plus-strand RNA and contains a single large open reading frame (ORF), a 5' untranslated region (5'UTR) and a 3' untranslated region (3'UTR). The ORF encodes a polyprotein, which is processed by viral and cellular proteases into mature proteins (the structural proteins in the N-terminal portion of the polyprotein whilst the replicative (non-structural or NS) proteins constitute the remainder).
The pestivirus NS3 protein is a multifunctional protein possessing serine protease, RNA helicase, and a nucleoside triphosphatase (NTPase) activities located in two functionally distinct domains. The N-terminal one-third of pestiviral NS3 primarily serves as a protease to process the viral polyprotein. The helicase and NTPase activities are localized to the C- terminal of NS3 protein [PUBMED:2543956, PUBMED:9603310, PUBMED:19951725]. The NS3 protease domain has approximately 180 aa with a catalytic triad of His-Asp-Ser. Positive regulation (activation) is observed by its interaction with NS4A. The pestivirus NS3 proteolytic domain constitutes MEROPS peptidase family S31 of clan PA.
This entry represents the pestivirus NS3 protease domain.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||serine-type endopeptidase activity (GO:0004252)|
|Biological process||proteolysis (GO:0006508)|
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This clan contains a diverse set of peptidases with the trypsin fold.
The clan contains the following 24 members:DUF1986 DUF31 DUF316 Peptidase_C24 Peptidase_C3 Peptidase_C30 Peptidase_C37 Peptidase_C3G Peptidase_C4 Peptidase_C62 Peptidase_S29 Peptidase_S3 Peptidase_S30 Peptidase_S31 Peptidase_S32 Peptidase_S39 Peptidase_S46 Peptidase_S55 Peptidase_S6 Peptidase_S7 Peptidase_S76 Pico_P2A Trypsin Trypsin_2
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||1|
|Number in full:||304|
|Average length of the domain:||183.60 aa|
|Average identity of full alignment:||90 %|
|Average coverage of the sequence by the domain:||6.68 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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