Summary: Mitochondrial protein Pet127
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Mitochondrial protein Pet127 Provide feedback
Pet127 has been implicated in mitochondrial RNA stability and/or processing and is localised to the mitochondrial membrane . The Pet127 family is part of the PD-(D/E)XK nuclease superfamily  including a full set of active site residues.
Wiesenberger G, Fox TD; , Mol Cell Biol. 1997;17:2816-2824.: Pet127p, a membrane-associated protein involved in stability and processing of Saccharomyces cerevisiae mitochondrial RNAs. PUBMED:9111353 EPMC:9111353
This tab holds annotation information from the InterPro database.
InterPro entry IPR013943
This entry represents a group of fungal mitochondria proteins, known as Pet127, that stimulate mitochondrial RNA degradation [PUBMED:17292401, PUBMED:9111353]. Pet127 has been classified as part of the PD-(D/E)XK nuclease superfamily including a full set of active site residues [PUBMED:20529888].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||mitochondrion (GO:0005739)|
|Biological process||mitochondrial RNA metabolic process (GO:0000959)|
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This clan includes a large number of nuclease families related to holliday junction resolvases [1,2].
The clan contains the following 127 members:ArenaCapSnatch BamHI BpuJI_N BpuSI_N Bse634I BsuBI_PstI_RE Cas_APE2256 Cas_Cas02710 Cas_Cas4 Cas_Csm6 Cas_DxTHG Cas_NE0113 CoiA Csa1 Dna2 DpnI DpnII DUF1016 DUF1780 DUF1887 DUF2034 DUF2161 DUF234 DUF2357 DUF2726 DUF2800 DUF2887 DUF3799 DUF3883 DUF4143 DUF4263 DUF4420 DUF559 EcoRI EcoRII-C eIF-3_zeta Endonuc-BglII Endonuc-BsobI Endonuc-EcoRV Endonuc-FokI_C Endonuc-HincII Endonuc-MspI Endonuc-PvuII Endonuc_BglI Endonuc_Holl ERCC4 Exo5 Flu_PA Herpes_alk_exo Herpes_UL24 Hjc HSDR_N HSDR_N_2 L_protein_N McrBC MepB MmcB-like Mrr_cat Mrr_cat_2 MutH MvaI_BcnI NaeI NERD NgoMIV_restric NotI NucS PDCD9 PDDEXK_1 PDDEXK_10 PDDEXK_2 PDDEXK_3 PDDEXK_4 PDDEXK_5 PDDEXK_7 PDDEXK_9 Pet127 Phage_endo_I R-HINP1I Rad10 RAI1 RAP RE_AlwI RE_ApaLI RE_Bpu10I RE_Bsp6I RE_CfrBI RE_Eco47II RE_EcoO109I RE_HaeII RE_HindIII RE_HindVP RE_HpaII RE_LlaJI RE_LlaMI RE_MjaI RE_NgoBV RE_NgoPII RE_SacI RE_ScaI RE_SinI RE_TaqI RE_TdeIII RE_XamI RE_XcyI RecU RestrictionMunI RestrictionSfiI RmuC RNA_pol_Rpb5_N Sen15 SfsA Spo0A_C TBPIP_N ThaI Tn7_Tnp_TnsA_N Transposase_31 tRNA_int_endo Tsp45I Uma2 UPF0102 VirArc_Nuclease VRR_NUC Vsr XhoI XisH YaeQ YqaJ
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Author:||Mistry J, Wood V|
|Number in seed:||98|
|Number in full:||399|
|Average length of the domain:||264.60 aa|
|Average identity of full alignment:||48 %|
|Average coverage of the sequence by the domain:||32.24 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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