Summary: PhoU domain
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PhoU domain Provide feedback
This family contains phosphate regulatory proteins including PhoU. PhoU proteins are known to play a role in the regulation of phosphate uptake. The PhoU domain is composed of a three helix bundle . The PhoU protein contains two copies of this domain. The domain binds to an iron cluster via its conserved E/DXXXD motif.
Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH; , J Biol Chem. 2005;280:15960-15966.: Crystal structure of a PhoU protein homologue: a new class of metalloprotein containing multinuclear iron clusters. PUBMED:15716271 EPMC:15716271
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR026022
PhoU proteins are known to play a role in the regulation of phosphate uptake. The PhoU domain is composed of a three helix bundle [PUBMED:15716271]. The PhoU protein contains two copies of this domain. The domain binds to an iron cluster via its conserved E/DXXXD motif. Deletion of PhoU activates constitutive expression of the phosphate ABC transporter and allows phosphate transport, but causes a growth defect; suggesting that the protein has some secondary function [PUBMED:8226621].
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Curation and family details
|Seed source:||Enright A|
|Author:||Enright A, Ouzounis C, Bateman A, Cerutti L, Dlakic M|
|Number in seed:||388|
|Number in full:||11541|
|Average length of the domain:||87.20 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||51.69 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||14|
|Download:||download the raw HMM for this family|
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There are 2 interactions for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PhoU domain has been found. There are 24 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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