Summary: PilS N terminal
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Type IV pili are bacterial virulence-associated adhesins that promote bacterial attachment to host cells. In Salmonella typhi, the structural pilin protein PilS interacts with the cystic fibrosis transmembrane conductance regulator . Mutagenesis studies suggest that residues on an alpha-beta loop and the C terminal disulphide-bonded region of PilS might be involved in binding specificity of the pilus .
Tsui IS, Yip CM, Hackett J, Morris C; , Infect Immun. 2003;71:6049-6050.: The type IVB pili of Salmonella enterica serovar Typhi bind to the cystic fibrosis transmembrane conductance regulator. PUBMED:14500527 EPMC:14500527
Xu XF, Tan YW, Lam L, Hackett J, Zhang M, Mok YK; , J Biol Chem. 2004;279:31599-31605.: NMR structure of a type IVb pilin from Salmonella typhi and its assembly into pilus. PUBMED:15159389 EPMC:15159389
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR014911
Type IV pili are bacterial virulence-associated adhesins that promote bacterial attachment to host cells. In Salmonella typhi, the structural pilin protein PilS interacts with the cystic fibrosis transmembrane conductance regulator [PUBMED:14500527]. Mutagenesis studies suggest that residues on an alpha-beta loop and the C-terminal disulphide-bonded region of PilS might be involved in binding specificity of the pilus [PUBMED:15159389].
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This is a clan contains bacterial pilus subunits and proteins involved in secretion. Pili proteins enable the transfer of plasmid between bacteria. The families in this clan adopt an alpha helical structure which is packed against a beta sheet [2-3].
The clan contains the following 10 members:Bundlin N_methyl N_methyl_2 N_methyl_3 Pilin PilS T2SG T2SI TcpA YadA_anchor
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Key: available, not generated, — not available.
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Curation and family details
|Number in seed:||18|
|Number in full:||332|
|Average length of the domain:||137.50 aa|
|Average identity of full alignment:||30 %|
|Average coverage of the sequence by the domain:||72.62 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PilS domain has been found. There are 5 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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