Summary: Plexin cytoplasmic RasGAP domain
Plexin cytoplasmic RasGAP domain Provide feedback
This family features the C-terminal regions of various plexins (e.g. P51805). Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels [1,2]. The cytoplasmic region, which has been called a SEX domain in some members of this family  is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins . This domain acts as a RasGAP domain .
Torres-Vazquez J, Gitler AD, Fraser SD, Berk JD, Van N Pham, Fishman MC, Childs S, Epstein JA, Weinstein BM; , Dev Cell 2004;7:117-123.: Semaphorin-plexin signaling guides patterning of the developing vasculature. PUBMED:15239959 EPMC:15239959
Fujii T, Nakao F, Shibata Y, Shioi G, Kodama E, Fujisawa H, Takagi S; , Development 2002;129:2053-2063.: Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis. PUBMED:11959816 EPMC:11959816
Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM; , Proc Natl Acad Sci U S A 1996;93:674-678.: A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. PUBMED:8570614 EPMC:8570614
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013548
This domain is found at C terminus of various plexins (e.g. SWISSPROT). Plexins are receptors for semaphorins, and plexin signalling is important in pathfinding and patterning of both neurons and developing blood vessels [PUBMED:15239959, PUBMED:11959816]. The cytoplasmic region, which has been called a SEX domain [PUBMED:8570614], and is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins [PUBMED:12559962].
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_3123 (release 18.0)|
|Number in seed:||11|
|Number in full:||880|
|Average length of the domain:||437.30 aa|
|Average identity of full alignment:||47 %|
|Average coverage of the sequence by the domain:||33.18 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Plexin_cytopl domain has been found. There are 19 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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