Summary: Poxvirus F12L protein
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Poxvirus F12L protein Provide feedback
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Internal database links
|Similarity to PfamA using HHSearch:||DNA_pol_B_2|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR005005
The vaccinia virus F12L gene encodes a 65 kDa protein that is expressed late during infection and is important for plaque formation, EEV production and virulence. The F12L protein is located on intracellular enveloped virus (IEV) particles, but is absent from immature virions, intracellular mature virus and cell-associated enveloped virus. F12L shows co-localization with endosomal compartments and microtubules and appears to play a role in the the transport of IEV particles to the cell surface on microtubules [PUBMED:11752717].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Biological process||viral reproduction (GO:0016032)|
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DNA polymerases replicate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of a growing chain of DNA. They use a complementary DNA chain as a template.`
The clan contains the following 4 members:DNA_pol_B DNA_pol_B_2 DUF1744 Pox_F12L
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Curation and family details
|Seed source:||Pfam-B_3082 (release 6.5)|
|Number in seed:||11|
|Number in full:||87|
|Average length of the domain:||615.20 aa|
|Average identity of full alignment:||60 %|
|Average coverage of the sequence by the domain:||99.36 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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