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The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain . The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration .
Corbeil D, Fargeas CA, Huttner WB; , Biochem Biophys Res Commun 2001;285:939-944.: Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein. PUBMED:11467842 EPMC:11467842
Maw MA, Corbeil D, Koch J, Hellwig A, Wilson-Wheeler JC, Bridges RJ, Kumaramanickavel G, John S, Nancarrow D, Roper K, Weigmann A, Huttner WB, Denton MJ; , Hum Mol Genet 2000;9:27-34.: A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration. PUBMED:10587575 EPMC:10587575
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR008795The prominins are an emerging family of proteins that, among the multispan membrane proteins, display a novel topology. Mouse and Homo sapiens prominin and (Mus musculus) prominin-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain [PUBMED:11467842]. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration [PUBMED:10587575].
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|Cellular component||integral to membrane (GO:0016021)|
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Curation and family details
|Seed source:||Pfam-B_18226 (release 8.0)|
|Number in seed:||14|
|Number in full:||435|
|Average length of the domain:||541.40 aa|
|Average identity of full alignment:||21 %|
|Average coverage of the sequence by the domain:||85.92 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
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