Summary: RNA polymerase I-specific transcription initiation factor Rrn7
RNA polymerase I-specific transcription initiation factor Rrn7 Provide feedback
Rrn7 is a transcription binding factor that associates strongly with both Rrn6 and Rrn11 to form a complex which itself binds the TATA-binding protein and is required for transcription by the core domain of the RNA PolI promoter [1,2].
Keys DA, Vu L, Steffan JS, Dodd JA, Yamamoto RT, Nogi Y, Nomura M; , Genes Dev. 1994;8:2349-2362.: RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae. PUBMED:7958901 EPMC:7958901
Lin CW, Moorefield B, Payne J, Aprikian P, Mitomo K, Reeder RH; , Mol Cell Biol. 1996;16:6436-6443.: A novel 66-kilodalton protein complexes with Rrn6, Rrn7, and TATA-binding protein to promote polymerase I transcription initiation in Saccharomyces cerevisiae. PUBMED:8887672 EPMC:8887672
Internal database links
|Similarity to PfamA using HHSearch:||TF_Zn_Ribbon Prim_Zn_Ribbon PhnA_Zn_Ribbon Zn_Tnp_IS1595|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR021752
Rrn7 is a transcription binding factor that associates strongly with both Rrn6 and Rrn11 to form a complex which itself binds the TATA-binding protein and is required for transcription by the core domain of the RNA PolI promoter [PUBMED:7958901],[PUBMED:8887672].
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a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
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A clan of zinc-binding ribbon domains.
The clan contains the following 50 members:A2L_zn_ribbon Auto_anti-p27 Baculo_LEF5_C DNA_RNApol_7kD DUF1610 DUF1936 DUF2116 DUF2180 DUF2387 DZR Elf1 GATA NinF NOB1_Zn_bind Ogr_Delta OrfB_Zn_ribbon PhnA_Zn_Ribbon Prim_Zn_Ribbon Ribosomal_L32p Ribosomal_L37ae Ribosomal_S27 Ribosomal_S27e RNA_POL_M_15KD RRN7 Spt4 TF_Zn_Ribbon TFIIS_C Tnp_zf-ribbon_2 Topo_Zn_Ribbon Toprim_Crpt Trm112p UPF0547 zf-C4_Topoisom zf-CHC2 zf-DHHC zf-dskA_traR zf-FPG_IleRS zf-GRF zf-NADH-PPase zf-RanBP zf-ribbon_3 zf-TFIIB zinc-ribbons_6 zinc_ribbon_2 zinc_ribbon_4 zinc_ribbon_5 Zn-ribbon_8 Zn_ribbon_recom Zn_Tnp_IS1 Zn_Tnp_IS1595
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_4705 (release 23.0)|
|Number in seed:||25|
|Number in full:||186|
|Average length of the domain:||34.60 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||6.39 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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