Summary: RNA dependent RNA polymerase
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RNA dependent RNA polymerase Provide feedback
This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses
Dinant S, Janda M, Kroner PA, Ahlquist P; , J Virol 1993;67:7181-7189.: Bromovirus RNA replication and transcription require compatibility between the polymerase- and helicase-like viral RNA synthesis proteins. PUBMED:8230440 EPMC:8230440
Koonin EV, Dolja VV; , Crit Rev Biochem Mol Biol 1993;28:375-430.: Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences. PUBMED:8269709 EPMC:8269709
Internal database links
|Similarity to PfamA using HHSearch:||RdRP_4|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001788
This entry represents RNA dependent RNA polymerases found in several types of viruses [PUBMED:8269709], especially those with a tripartite genome (RNA1, RNA2 and RNA3) and an encapsidated subgenomic RNA (RNA4) from which the coat protein is expressed, such as Cucumber mosaic virus (strain NT9) (CMV). This entry contains the following proteins:
- Viral RNA-directed RNA polymerase 2A (protein 2A) [PUBMED:15746101].
- Putative RNA dependent RNA polymerase from Tobacco mosaic virus [PUBMED:8709249].
- Non structural polyprotein from Togavirus [PUBMED:8445717].
|Molecular function||RNA binding (GO:0003723)|
|RNA-directed RNA polymerase activity (GO:0003968)|
|Biological process||transcription, DNA-dependent (GO:0006351)|
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Curation and family details
|Seed source:||Pfam-B_13 (release 3.0)|
|Author:||Finn RD, Bateman A, Griffiths-Jones SR|
|Number in seed:||36|
|Number in full:||2606|
|Average length of the domain:||250.60 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||29.18 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||16|
|Download:||download the raw HMM for this family|
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