Summary: Reovirus viral attachment protein sigma 1
This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
Reovirus viral attachment protein sigma 1 Provide feedback
This family consists of the reovirus sigma 1 hemagglutinin, cell attachment protein. This glycoprotein is a minor capsid protein and also determines the serotype-specific humoral immune response. Sigma 1 consist of a fibrous tail and a globular head. The head has important roles in the cell attachment function of sigma 1 and determinant of the type-specific humoral immune response . Reovirus is part of the orthoreovirus group of retroviruses with, a dsRNA genome. Also present in this family is bacteriophage SF6 Lysozyme P21270.
Dermody TS, Nibert ML, Bassel-Duby R, Fields BN; , J Virol 1990;64:4842-4850.: Sequence diversity in S1 genes and S1 translation products of 11 serotype 3 reovirus strains. PUBMED:2398530 EPMC:2398530
Duncan R, Horne D, Cashdollar LW, Joklik WK, Lee PW; , Virology 1990;174:399-409.: Identification of conserved domains in the cell attachment proteins of the three serotypes of reovirus. PUBMED:2305549 EPMC:2305549
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR002592
This family consists of the Reovirus sp. sigma 1 haemagglutinin, cell attachment protein. This glycoprotein is a minor capsid protein and also determines the serotype-specific humoral immune response. Sigma 1 consist of a fibrous tail and a globular head. The head has important roles in the cell attachment function of sigma 1 and determinant of the type-specific humoral immune response [PUBMED:2398530]. Reovirus sp. are part of the Orthoreovirus group of Reoviridae with a dsRNA genome. Also present in this family is Bacteriophage SF6 lysozyme SWISSPROT.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Biological process||cell adhesion (GO:0007155)|
|virion attachment to host cell (GO:0019062)|
|viral life cycle (GO:0019058)|
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_1003 (release 4.1)|
|Author:||Bashton M, Bateman A|
|Number in seed:||3|
|Number in full:||77|
|Average length of the domain:||210.30 aa|
|Average identity of full alignment:||62 %|
|Average coverage of the sequence by the domain:||46.73 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Reo_sigma1 domain has been found. There are 36 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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