Summary: Glycine zipper 2TM domain
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Glycine zipper 2TM domain Provide feedback
This family includes a putative two transmembrane alpha-helical region that contains glycine zipper motifs . This family includes several Rickettsia genus specific 17 kDa surface antigen proteins .
Anderson BE, Baumstark BR, Bellini WJ; , J Bacteriol 1988;170:4493-4500.: Expression of the gene encoding the 17-kilodalton antigen from Rickettsia rickettsii: transcription and posttranslational modification. PUBMED:3139629 EPMC:3139629
Kim S, Jeon TJ, Oberai A, Yang D, Schmidt JJ, Bowie JU;, Proc Natl Acad Sci U S A. 2005;102:14278-14283.: Transmembrane glycine zippers: physiological and pathological roles in membrane proteins. PUBMED:16179394 EPMC:16179394
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR008816
This domain includes a putative two transmembrane alpha-helical region that contains glycine zipper motifs [PUBMED:16179394]. The domain is found in several Rickettsia genus specific 17 kDa surface antigen proteins [PUBMED:3139629].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||outer membrane (GO:0019867)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
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This superfamily is characterised by having long glycine-zipper motifs, characteristically GxxxGxxxG , often with several contiguous copies. The x following the G is frequently found to be an alanine. This sequence region can be found in both symmetric and non-symmetrical membrane structures, and is relatively common. The fact that such a large fraction of the relatively few known membrane channel structures use the glycine zipper suggests that the sequence motif plays a special role in forming these homo-oligomeric bundles .
The clan contains the following 5 members:DUF1269 Gly-zipper_Omp Gly-zipper_OmpA Gly-zipper_YMGG Rick_17kDa_Anti
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
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Curation and family details
|Seed source:||Pfam-B_13382 (Rel 8.0) & Pfam-B_6 (Rel 24.0)|
|Author:||Moxon SJ, Bateman A|
|Number in seed:||174|
|Number in full:||3882|
|Average length of the domain:||41.70 aa|
|Average identity of full alignment:||44 %|
|Average coverage of the sequence by the domain:||28.29 %|
|HMM build commands:||
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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