Summary: Rifin/stevor family
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Rifin/stevor family Provide feedback
Several multicopy gene families have been described in Plasmodium falciparum, including the stevor family of subtelomeric open reading frames and the rif interspersed repetitive elements. Both families contain three predicted transmembrane segments. It has been proposed that stevor and rif are members of a larger superfamily that code for variant surface antigens .
Cheng Q, Cloonan N, Fischer K, Thompson J, Waine G, Lanzer M, Saul A; , Mol Biochem Parasitol 1998;97:161-176.: Stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. PUBMED:9879895 EPMC:9879895
Kyes SA, Rowe JA, Kriek N, Newbold CI; , Proc Natl Acad Sci U S A 1999;96:9333-9338.: Rifins: a second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum. PUBMED:10430943 EPMC:10430943
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This tab holds annotation information from the InterPro database.
InterPro entry IPR002858
Malaria is still a major cause of mortality in many areas of the world. Plasmodium falciparum causes the most severe human form of the disease and is responsible for most fatalities. Severe cases of malaria can occur when the parasite invades and then proliferates within red blood cell erythrocytes. The parasite produces many variant antigenic proteins, encoded by multigene families, which are present on the surface of the infected erythrocyte and play important roles in virulence. A crucial survival mechanism for the malaria parasite is its ability to evade the immune response by switching these variant surface antigens. The high virulence of P. falciparum relative to other malarial parasites is in large part due to the fact that in this organism many of these surface antigens mediate the binding of infected erythrocytes to the vascular endothelium (cytoadherence) and non-infected erythrocytes (rosetting). This can lead to the accumulation of infected cells in the vasculature of a variety of organs, blocking the blood flow and reducing the oxygen supply. Clinical symptoms of severe infection can include fever, progressive anaemia, multi-organ dysfunction and coma. For more information see [PUBMED:10885986].Several multicopy gene families have been described in Plasmodium falciparum, including the stevor family of subtelomeric open reading frames and the rif interspersed repetitive elements. Both families contain three predicted transmembrane segments. It has been proposed that stevor and rif are members of a larger superfamily that code for variant surface antigens [PUBMED:9879895].
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Curation and family details
|Seed source:||Lawson D|
|Author:||Bateman A, Lawson D|
|Number in seed:||16|
|Number in full:||412|
|Average length of the domain:||288.50 aa|
|Average identity of full alignment:||30 %|
|Average coverage of the sequence by the domain:||96.01 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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