Summary: Rtf2 RING-finger
Rtf2 RING-finger Provide feedback
It is vital for effective cell-replication that replication is not stalled at any point by, for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilizes the replication fork stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif, and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+ ion-binding site . This domain is also found at the N-terminus of peptidyl-prolyl cis-trans isomerase 4, a divergent cyclophilin family .
Inagawa T, Yamada-Inagawa T, Eydmann T, Mian IS, Wang TS, Dalgaard JZ;, Proc Natl Acad Sci U S A. 2009;106:7927-7932.: Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart. PUBMED:19416828 EPMC:19416828
Page AP, Winter AD;, Mol Biochem Parasitol. 1998;95:215-227.: A divergent multi-domain cyclophilin is highly conserved between parasitic and free-living nematode species and is important in larval muscle development. PUBMED:9803414 EPMC:9803414
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This tab holds annotation information from the InterPro database.
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Gladomain, followed by two consecutive
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This clan includes the Ring zinc finger domains as well as the U-box domain that appears to have lost the zinc coordinating cysteine residues .
The clan contains the following 24 members:Baculo_RING FANCL_C Prok-RING_1 Prok-RING_2 Prok-RING_4 RINGv Rtf2 U-box zf-Apc11 zf-C3HC4 zf-C3HC4_2 zf-C3HC4_3 zf-C3HC4_4 zf-MIZ zf-Nse zf-rbx1 zf-RING-like zf-RING_2 zf-RING_4 zf-RING_5 zf-RING_6 zf-RING_UBOX zf-UBP zf-UDP
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Curation and family details
|Seed source:||Pfam-B_5482 (release 7.5)|
|Author:||Mifsud W, Pollington J|
|Number in seed:||23|
|Number in full:||575|
|Average length of the domain:||231.20 aa|
|Average identity of full alignment:||20 %|
|Average coverage of the sequence by the domain:||66.07 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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