Summary: SEFIR domain
SEFIR domain Provide feedback
This family comprises IL17 receptors (IL17Rs, e.g. Q60943) and SEF proteins (e.g. Q8QHJ9). The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (PF01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways .
Novatchkova M, Leibbrandt A, Werzowa J, Neubuser A, Eisenhaber F; , Trends Biochem Sci 2003;28:226-229.: The STIR-domain superfamily in signal transduction, development and immunity. PUBMED:12765832 EPMC:12765832
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013568
This domain is found in IL17 receptors (IL17Rs, e.g. SWISSPROT) and SEF proteins (e.g. SWISSPROT). The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (INTERPRO), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways [PUBMED:12765832].
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Both members of this clan are thought to be involved in TOLL/IL1R-like pathways, by mediating protein-protein interactions between pathway components. The N-termini of SEFIR and TIR domains are similar, but the domains are more divergent towards the C-terminus .
The clan contains the following 5 members:DUF1863 SEFIR TIR TIR-like TIR_2
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_33671 (release 17.0)|
|Number in seed:||15|
|Number in full:||821|
|Average length of the domain:||137.90 aa|
|Average identity of full alignment:||21 %|
|Average coverage of the sequence by the domain:||26.48 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SEFIR domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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