Summary: SLA1 homology domain 1, SHD1
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SLA1 homology domain 1, SHD1 Provide feedback
NPFXD peptides specifically interact with the SHD1 domain. NPFXD is a clathrin-facilitated endocytic targeting signal. NPFXD was originally discovered in the cytoplasmic domain of the furin-like protease Kex2p . Sla1 is thought to function as an endocytic adaptor .
Tang HY, Xu J, Cai M; , Mol Cell Biol 2000;20:12-25.: Pan1p, End3p, and S1a1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis. PUBMED:10594004 EPMC:10594004
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007131
The SLA1 homology domain is found in the cytoskeleton assembly control protein SLA1, which is responsible for the correct formation of the actin cytoskeleton.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||ubiquitin binding (GO:0043130)|
|identical protein binding (GO:0042802)|
|protein binding, bridging (GO:0030674)|
|cytoskeletal protein binding (GO:0008092)|
- the number of sequences which exhibit this architecture
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_ (release 7.2)|
|Author:||Finn RD, Wood V|
|Number in seed:||18|
|Number in full:||166|
|Average length of the domain:||68.70 aa|
|Average identity of full alignment:||47 %|
|Average coverage of the sequence by the domain:||6.66 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SHD1 domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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