Summary: Serine hydroxymethyltransferase
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Serine hydroxymethyltransferase Provide feedback
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Internal database links
|SCOOP:||DegT_DnrJ_EryC1 Cys_Met_Meta_PP Beta_elim_lyase OKR_DC_1 Flg_hook SelA DUF1950 DUF3557 DUF4157|
|Similarity to PfamA using HHSearch:||Aminotran_1_2 Aminotran_5 DegT_DnrJ_EryC1 Cys_Met_Meta_PP Beta_elim_lyase|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001085
Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP) dependent enzyme and belongs to the aspartate aminotransferase superfamily (fold type I) [PUBMED:10828359]. The pyridoxal-P group is attached to a lysine residue around which the sequence is highly conserved in all forms of the enzyme [PUBMED:8305478]. The enzyme carries out interconversion of serine and glycine using PLP as the cofactor. SHMT catalyses the transfer of a hydroxymethyl group from N5, N10- methylene tetrahydrofolate to glycine, resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers and the mammalian enzyme forms a homotetramer [PUBMED:10828359, PUBMED:11877399].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||glycine hydroxymethyltransferase activity (GO:0004372)|
|Biological process||glycine metabolic process (GO:0006544)|
|L-serine metabolic process (GO:0006563)|
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This superfamily contains a variety of PLP-dependent enzymes.
The clan contains the following 15 members:Alliinase_C Aminotran_1_2 Aminotran_3 Aminotran_5 Aminotran_MocR Beta_elim_lyase Cys_Met_Meta_PP DegT_DnrJ_EryC1 GDC-P Met_gamma_lyase OKR_DC_1 Pyridoxal_deC SelA SepSecS SHMT
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Curation and family details
|Number in seed:||12|
|Number in full:||25845|
|Average length of the domain:||360.50 aa|
|Average identity of full alignment:||58 %|
|Average coverage of the sequence by the domain:||89.43 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SHMT domain has been found. There are 131 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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