Summary: SICA extracellular alpha domain
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The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies. This domain is typically found at the N-terminus, with 1 or 2 copies per protein. The domain is cysteine-rich domain and similar to PFAM:PF12878 .
Pain A, Bohme U, Berry AE, Mungall K, Finn RD, Jackson AP, Mourier T, Mistry J, Pasini EM, Aslett MA, Balasubrammaniam S, Borgwardt K, Brooks K, Carret C, Carver TJ, Cherevach I, Chillingworth T, Clark TG, Galinski MR, Hall N, Harper D, Harris D, Hauser H, Ivens A, Janssen CS, Keane T, Larke N, Lapp S, Marti M, Moule S, Meyer IM, Ormond D, Peters N, Sanders M, Sanders S, Sargeant TJ, Simmonds M, Smith F, Squares R, Thurston S, Tivey AR, Walker D, White B, Zuiderwijk E, Churcher C, Quail MA, Cowman AF, Turner CM, Rajandream MA, Kocken CH, Thomas AW, Newbold CI, Barrell BG, Berriman M;, Nature. 2008;455:799-803.: The genome of the simian and human malaria parasite Plasmodium knowlesi. PUBMED:18843368 EPMC:18843368
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024290
The schizont-infected cell agglutination (SICA) proteins of Plasmodium knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. SICA proteins comprise multiple domains, with the extracellular cysteine-rich domains (CRDs) occurring at different frequencies. They contain a five-cysteine CRD (SICA-alpha) at the N terminus, which occurs once or twice, then between 1 and 10 SICA-beta CRDs with 7-10 cysteine residues, a transmembrane domain, and a conserved C-terminal domain [PUBMED:18843368].
This entry represents the extracellular SICA-alpha domain.
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The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of three domains (alpha, beta and C-terminal). The two extracelullar domains, termed SICA alpha and beta, occur with varying copy number. The alpha domain, although it appears to be related to the beta domain, contains few cysteine residues and is found between 1 and 2 times, compared with the beta domain that occurs between 1 and 10 times (when present) .
The clan contains the following 2 members:SICA_alpha SICA_beta
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Curation and family details
|Number in seed:||71|
|Number in full:||105|
|Average length of the domain:||180.80 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||21.68 %|
|HMM build commands:||
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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