Summary: Transmembrane alpha-helix domain
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Transmembrane alpha-helix domain Provide feedback
SKG6/Axl2 are membrane proteins that show polarised intracellular localisation . SKG6_Tmem is the highly conserved transmembrane alpha-helical domain of SKG6 and Axl2 proteins  . The full-length fungal protein has a negative regulatory function in cytokinesis .
Tomishige N, Noda Y, Adachi H, Yoda K; , J Gen Appl Microbiol. 2005;51:323-326.: SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. PUBMED:16314687 EPMC:16314687
Gandhi M, Goode BL, Chan CS; , Genetics. 2006;174:665-678.: Four novel suppressors of gic1 gic2 and their roles in cytokinesis and polarized cell growth in Saccharomyces cerevisiae. PUBMED:16816427 EPMC:16816427
Gao XD, Sperber LM, Kane SA, Tong Z, Tong AH, Boone C, Bi E; , Mol Biol Cell. 2007;18:2542-2560.: Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle. PUBMED:17460121 EPMC:17460121
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR014805
SKG6 and AXL2 are membrane proteins that show polarised intracellular localisation [PUBMED:17460121, PUBMED:16314687]. This entry represents the highly conserved transmembrane alpha-helical domain found in these proteins [PUBMED:17460121, PUBMED:16816427]. The full-length AXL2 protein has a negative regulatory function in cytokinesis [PUBMED:16816427].
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Curation and family details
|Seed source:||manual, Wood V|
|Author:||Mistry J, Coggill P|
|Number in seed:||13|
|Number in full:||66|
|Average length of the domain:||38.70 aa|
|Average identity of full alignment:||41 %|
|Average coverage of the sequence by the domain:||5.65 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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