Summary: Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen)
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Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Provide feedback
This family consists of several eukaryotic and archaeal proteins which are related to the human soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen). Autoantibodies are a hallmark of autoimmune hepatitis, but most are not disease specific. Autoantibodies to soluble liver antigen (SLA) and to liver and pancreas antigen (LP) have been described as disease specific, occurring in about 30% of all patients with autoimmune hepatitis . The function of SLA/LP is unknown, however, it has been suggested that the protein may function as a serine hydroxymethyltransferase and may be an important enzyme in the thus far poorly understood selenocysteine pathway . The archaeal sequences Q8TXK0 and Q8TYR3 are annotated as being pyridoxal phosphate-dependent enzymes.
Wies I, Brunner S, Henninger J, Herkel J, Kanzler S, Meyer zum Buschenfelde KH, Lohse AW; , Lancet 2000;355:1510-1515.: Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis. PUBMED:10801173 EPMC:10801173
Kernebeck T, Lohse AW, Grotzinger J; , Hepatology 2001;34:230-233.: A bioinformatical approach suggests the function of the autoimmune hepatitis target antigen soluble liver antigen/liver pancreas. PUBMED:11481605 EPMC:11481605
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR008829This family consists of several eukaryotic and archaeal proteins which are related to the Homo sapiens soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen). Autoantibodies are a hallmark of autoimmune hepatitis, but most are not disease specific. Autoantibodies to soluble liver antigen (SLA) and to liver and pancreas antigen (LP) have been described as disease specific, occurring in about 30% of all patients with autoimmune hepatitis [PUBMED:10801173]. The function of SLA/LP is unknown, however, it has been suggested that the protein may function as a serine hydroxymethyltransferase and may be an important enzyme in the thus far poorly understood selenocysteine pathway [PUBMED:11481605]. The archaeal sequences SWISSPROT and SWISSPROT are annotated as being pyridoxal phosphate-dependent enzymes.
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|Molecular function||transferase activity (GO:0016740)|
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This superfamily contains a variety of PLP-dependent enzymes.
The clan contains the following 15 members:Alliinase_C Aminotran_1_2 Aminotran_3 Aminotran_5 Aminotran_MocR Beta_elim_lyase Cys_Met_Meta_PP DegT_DnrJ_EryC1 GDC-P Met_gamma_lyase OKR_DC_1 Pyridoxal_deC SelA SHMT SLA_LP_auto_ag
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Curation and family details
|Seed source:||Pfam-B_9614 (release 8.0)|
|Number in seed:||5|
|Number in full:||254|
|Average length of the domain:||327.70 aa|
|Average identity of full alignment:||33 %|
|Average coverage of the sequence by the domain:||79.28 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SLA_LP_auto_ag domain has been found. There are 15 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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