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69  structures 1455  species 0  interactions 13323  sequences 223  architectures

Family: SNARE (PF05739)

Summary: SNARE domain

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The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

SNARE domain Provide feedback

Most if not all vesicular membrane fusion events in eukaryotic cells are believed to be mediated by a conserved fusion machinery, the SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors] machinery. The SNARE domain is thought to act as a protein-protein interaction module in the assembly of a SNARE protein complex [1].

Literature references

  1. Weimbs T, Low SH, Chapin SJ, Mostov KE, Bucher P, Hofmann K; , Proc Natl Acad Sci U S A 1997;94:3046-3051.: A conserved domain is present in different families of vesicular fusion proteins: a new superfamily. PUBMED:9096343 EPMC:9096343


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000727

The process of vesicular fusion with target membranes depends on a set of SNAREs (SNAP-Receptors), which are associated with the fusing membranes [ PUBMED:9239749 , PUBMED:9232812 ]. Target SNAREs (t-SNAREs) are localised on the target membrane and belong to two different families, the syntaxin-like family and the SNAP-25 like family. One member of each family, together with a v-SNARE localised on the vesicular membrane, are required for fusion.

The N- and C-terminal coiled-coil domains of members of the SNAP-25 family and the most C-terminal coiled-coil domain of the syntaxin family are related to each other and form a new homology domain of approximately 60 amino acids. This domain is also found in other known proteins involved in vesicular membrane traffic, some of which belong to different protein families [ PUBMED:9096343 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(64)
Full
(13323)
Representative proteomes UniProt
(22392)
RP15
(2267)
RP35
(6106)
RP55
(10743)
RP75
(14545)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(64)
Full
(13323)
Representative proteomes UniProt
(22392)
RP15
(2267)
RP35
(6106)
RP55
(10743)
RP75
(14545)
Alignment:
Format:
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Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(64)
Full
(13323)
Representative proteomes UniProt
(22392)
RP15
(2267)
RP35
(6106)
RP55
(10743)
RP75
(14545)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_6285 (release 8.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Moxon SJ
Number in seed: 64
Number in full: 13323
Average length of the domain: 52.00 aa
Average identity of full alignment: 24 %
Average coverage of the sequence by the domain: 17.15 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.8 26.8
Trusted cut-off 26.8 26.8
Noise cut-off 26.7 26.7
Model length: 53
Family (HMM) version: 21
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SNARE domain has been found. There are 69 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0A0MPL4 View 3D Structure Click here
A0A0G2K528 View 3D Structure Click here
A0A0P0WQ70 View 3D Structure Click here
A0A0P0X6V1 View 3D Structure Click here
A0A0R0GJ24 View 3D Structure Click here
A0A0R0H6G9 View 3D Structure Click here
A0A0R0H7I4 View 3D Structure Click here
A0A0R4ICQ9 View 3D Structure Click here
A0A0R4IK07 View 3D Structure Click here
A0A1D6GG21 View 3D Structure Click here
A0A1D6GI53 View 3D Structure Click here
A0A1D6HHG5 View 3D Structure Click here
A0A1D6HSW4 View 3D Structure Click here
A0A1D6I2Q2 View 3D Structure Click here
A0A1D6L384 View 3D Structure Click here
A0A1D6L6W5 View 3D Structure Click here
A0A1D6LSK3 View 3D Structure Click here
A0A1D6MBX4 View 3D Structure Click here
A0A1D6MXV0 View 3D Structure Click here
A0A1D6N0J7 View 3D Structure Click here
A0A1D6PI21 View 3D Structure Click here
A0A1D6QQM6 View 3D Structure Click here
A0A1D8PGJ1 View 3D Structure Click here
A0A1D8PK25 View 3D Structure Click here
A0A1D8PNI0 View 3D Structure Click here
A0A1D8PSE4 View 3D Structure Click here
A0A1R3QVV0 View 3D Structure Click here
A0A2R8QH11 View 3D Structure Click here
A0A2R8QRW0 View 3D Structure Click here
A0A2R8RKH5 View 3D Structure Click here
A0A2R8RWS3 View 3D Structure Click here
A4HZL4 View 3D Structure Click here
A4I201 View 3D Structure Click here
A4I7H0 View 3D Structure Click here
A4I905 View 3D Structure Click here
A4IBD9 View 3D Structure Click here
A5PMJ7 View 3D Structure Click here
B4F8C8 View 3D Structure Click here
B4FBM0 View 3D Structure Click here
B4FBQ6 View 3D Structure Click here
B4FEN4 View 3D Structure Click here
B4FLD1 View 3D Structure Click here
B6TDM3 View 3D Structure Click here
B6THW9 View 3D Structure Click here
C6TA84 View 3D Structure Click here
C6TBP9 View 3D Structure Click here
C6THU9 View 3D Structure Click here
C6TJZ6 View 3D Structure Click here
C6TKX1 View 3D Structure Click here
C6TNI1 View 3D Structure Click here
D3ZUH2 View 3D Structure Click here
E7EXN4 View 3D Structure Click here
E7F0D3 View 3D Structure Click here
E7F2P0 View 3D Structure Click here
E9AGR4 View 3D Structure Click here
E9AHG5 View 3D Structure Click here
F1QIQ6 View 3D Structure Click here
F1QX22 View 3D Structure Click here
G3V7P1 View 3D Structure Click here
I1J4T0 View 3D Structure Click here
I1J8T7 View 3D Structure Click here
I1JD32 View 3D Structure Click here
I1JGG8 View 3D Structure Click here
I1JGG9 View 3D Structure Click here
I1JI73 View 3D Structure Click here
I1JQ97 View 3D Structure Click here
I1JQP7 View 3D Structure Click here
I1JUJ6 View 3D Structure Click here
I1JUJ8 View 3D Structure Click here
I1K911 View 3D Structure Click here
I1K912 View 3D Structure Click here
I1KQP4 View 3D Structure Click here
I1KYD6 View 3D Structure Click here
I1L4Z2 View 3D Structure Click here
I1L8U0 View 3D Structure Click here
I1L9L2 View 3D Structure Click here
I1L9L3 View 3D Structure Click here
I1LB67 View 3D Structure Click here
I1LHU2 View 3D Structure Click here
I1LU69 View 3D Structure Click here
I1LZ35 View 3D Structure Click here
I1M2C2 View 3D Structure Click here
I1M6L1 View 3D Structure Click here
I1M6Q8 View 3D Structure Click here
I1M7V7 View 3D Structure Click here
I1MEA9 View 3D Structure Click here
I1ML76 View 3D Structure Click here
I1MMC2 View 3D Structure Click here
I1MNS3 View 3D Structure Click here
I1MNV4 View 3D Structure Click here
I1N0I7 View 3D Structure Click here
I1N0N7 View 3D Structure Click here
I1NA77 View 3D Structure Click here
I1NAV2 View 3D Structure Click here
I1NJ45 View 3D Structure Click here
K7LVG0 View 3D Structure Click here
K7MXQ1 View 3D Structure Click here
K7VES8 View 3D Structure Click here
M0R930 View 3D Structure Click here
O13644 View 3D Structure Click here
O14222 View 3D Structure Click here
O14662 View 3D Structure Click here
O15400 View 3D Structure Click here
O16000 View 3D Structure Click here
O35526 View 3D Structure Click here
O43752 View 3D Structure Click here
O60499 View 3D Structure Click here
O62236 View 3D Structure Click here
O62387 View 3D Structure Click here
O64791 View 3D Structure Click here
O65359 View 3D Structure Click here
O70257 View 3D Structure Click here
O70439 View 3D Structure Click here
O88983 View 3D Structure Click here
O94651 View 3D Structure Click here
O96189 View 3D Structure Click here
P32851 View 3D Structure Click here
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P32856 View 3D Structure Click here
P32867 View 3D Structure Click here
P39926 View 3D Structure Click here
P50279 View 3D Structure Click here
P61264 View 3D Structure Click here
P61265 View 3D Structure Click here
P61266 View 3D Structure Click here
P70452 View 3D Structure Click here
P83528 View 3D Structure Click here
P91409 View 3D Structure Click here
P93654 View 3D Structure Click here
Q00262 View 3D Structure Click here
Q01590 View 3D Structure Click here
Q08144 View 3D Structure Click here
Q08849 View 3D Structure Click here
Q08850 View 3D Structure Click here
Q08851 View 3D Structure Click here
Q0DYC1 View 3D Structure Click here
Q12241 View 3D Structure Click here
Q12846 View 3D Structure Click here
Q13190 View 3D Structure Click here
Q13277 View 3D Structure Click here
Q16623 View 3D Structure Click here
Q1MTI1 View 3D Structure Click here
Q20024 View 3D Structure Click here
Q20574 View 3D Structure Click here
Q20797 View 3D Structure Click here
Q24509 View 3D Structure Click here
Q24547 View 3D Structure Click here
Q2RA30 View 3D Structure Click here
Q39233 View 3D Structure Click here
Q42374 View 3D Structure Click here
Q4CMH5 View 3D Structure Click here
Q4CTS6 View 3D Structure Click here
Q4CYJ1 View 3D Structure Click here
Q4D090 View 3D Structure Click here
Q4D8X0 View 3D Structure Click here
Q4DCA3 View 3D Structure Click here
Q4DF21 View 3D Structure Click here
Q4DFA3 View 3D Structure Click here
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Q4DK29 View 3D Structure Click here
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Q4E2V6 View 3D Structure Click here
Q54HM5 View 3D Structure Click here
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Q54RN7 View 3D Structure Click here
Q54WF8 View 3D Structure Click here
Q54X86 View 3D Structure Click here
Q54ZH1 View 3D Structure Click here
Q551H5 View 3D Structure Click here
Q553P5 View 3D Structure Click here
Q55DR2 View 3D Structure Click here
Q59YF0 View 3D Structure Click here
Q5ABD1 View 3D Structure Click here
Q5AKC2 View 3D Structure Click here
Q5JMS0 View 3D Structure Click here
Q5VRF6 View 3D Structure Click here
Q5VRL4 View 3D Structure Click here
Q63635 View 3D Structure Click here
Q64704 View 3D Structure Click here
Q69X85 View 3D Structure Click here
Q6DG84 View 3D Structure Click here
Q6F3B4 View 3D Structure Click here
Q6H8D0 View 3D Structure Click here
Q6PHV0 View 3D Structure Click here
Q6YUT2 View 3D Structure Click here
Q6Z1L9 View 3D Structure Click here
Q7JY00 View 3D Structure Click here
Q7K0X9 View 3D Structure Click here
Q7KVY7 View 3D Structure Click here
Q7T361 View 3D Structure Click here
Q7XIE2 View 3D Structure Click here
Q84R43 View 3D Structure Click here
Q86Y82 View 3D Structure Click here
Q8BVI5 View 3D Structure Click here
Q8IE08 View 3D Structure Click here
Q8K1E0 View 3D Structure Click here
Q8VZU2 View 3D Structure Click here
Q946Y7 View 3D Structure Click here
Q94KK5 View 3D Structure Click here
Q94KK6 View 3D Structure Click here
Q94KK7 View 3D Structure Click here
Q96NA8 View 3D Structure Click here
Q9C615 View 3D Structure Click here
Q9ER00 View 3D Structure Click here
Q9FFK1 View 3D Structure Click here
Q9HGN3 View 3D Structure Click here
Q9JKK1 View 3D Structure Click here
Q9LGF8 View 3D Structure Click here
Q9LK09 View 3D Structure Click here
Q9P6P1 View 3D Structure Click here
Q9S7H0 View 3D Structure Click here
Q9SA23 View 3D Structure Click here
Q9SF29 View 3D Structure Click here
Q9SRV7 View 3D Structure Click here
Q9SUJ1 View 3D Structure Click here
Q9SVC2 View 3D Structure Click here
Q9SWH4 View 3D Structure Click here
Q9SXB0 View 3D Structure Click here
Q9TY08 View 3D Structure Click here
Q9UNK0 View 3D Structure Click here
Q9USH7 View 3D Structure Click here
Q9VR90 View 3D Structure Click here
Q9VU45 View 3D Structure Click here
Q9VV76 View 3D Structure Click here
Q9VVX6 View 3D Structure Click here
Q9Z2Q7 View 3D Structure Click here
Q9ZPV9 View 3D Structure Click here
Q9ZQZ8 View 3D Structure Click here
Q9ZSD4 View 3D Structure Click here
X1WEE0 View 3D Structure Click here