Summary: SOCS box
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SOCS box Provide feedback
The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001496
The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signalling (SOCS) family [PUBMED:9202125] but was later also found in:
- the WSB (WD-40-repeat-containing proteins with a SOCS box) family,
- the SSB (SPRY domain-containing proteins with a SOCS box) family,
- the ASB (ankyrin-repeat-containing proteins with a SOCS box) family,
- and ras and ras-like GTPases [PUBMED:9419338].
The SOCS box found in these proteins is an about 50 amino acid carboxy-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 non-conserved residues [PUBMED:9419338]. The C-terminal conserved region is an L/P-rich sequence of unknown function, whereas the N-terminal conserved region is a consensus BC box [PUBMED:9869640], which binds to the Elongin BC complex [PUBMED:9869640, PUBMED:10051596]. It has been proposed that this association could couple bound proteins to the ubiquitination or proteasomal compartments [PUBMED:10051596].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Biological process||intracellular signal transduction (GO:0035556)|
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Curation and family details
|Previous IDs:||Clip; SOCS_Clip;|
|Number in seed:||477|
|Number in full:||3249|
|Average length of the domain:||38.60 aa|
|Average identity of full alignment:||35 %|
|Average coverage of the sequence by the domain:||9.82 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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There are 5 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SOCS_box domain has been found. There are 9 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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