Summary: Scavenger receptor cysteine-rich domain
Scavenger receptor cysteine-rich domain Provide feedback
SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.
Yamaguchi N, Okui A, Yamada T, Nakazato H, Mitsui S;, J Biol Chem. 2002;277:6806-6812.: Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord. PUBMED:11741986 EPMC:11741986
Internal database links
|Similarity to PfamA using HHSearch:||SRCR Hepsin-SRCR|
External database links
This tab holds annotation information from the InterPro database.
No InterPro data for this Pfam family.
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
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We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Rawlings ND|
|Number in seed:||45|
|Number in full:||550|
|Average length of the domain:||93.60 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||15.14 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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The tree shows the occurrence of this domain across different species. More...
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