Summary: Exocyst complex component Sec3
Exocyst complex component Sec3 Provide feedback
This entry is the conserved middle and C-terminus of the Sec3 protein. Sec3 binds to the C-terminal cytoplasmic domain of GLYT1 (glycine transporter protein 1). Sec3 is the exocyst component that is closest to the plasma membrane docking site and it serves as a spatial landmark in the plasma membrane for incoming secretory vesicles. Sec3 is recruited to the sites of polarised membrane growth through its interaction with Rho1p, a small GTP-binding protein.
Internal database links
|Similarity to PfamA using HHSearch:||Vps52|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019160
The exocyst complex is composed of 8 subunits: Exoc1, Exoc2, Exoc3, Exoc4, Exoc5, Exoc6, Exoc7 and Exoc8. This entry represents the subunit Exoc1 (Sec3).
Sec3 binds to the C-terminal cytoplasmic domain of GLYT1 (glycine transporter protein 1). Sec3 is the exocyst component that is closest to the plasma membrane docking site and it serves as a spatial landmark in the plasma membrane for incoming secretory vesicles. Sec3 is recruited to the sites of polarised membrane growth through its interaction with Rho1p, a small GTP-binding protein.
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This clan includes an N-terminal domain from several vesicle transport proteins that are related to Vps51.
The clan contains the following 16 members:COG2 COG5 COG6 Dor1 DUF2450 Exo70 Sec15 Sec3_C Sec3_C_2 Sec5 Sec6 Sec8_exocyst Vps51 Vps52 Vps53_N Zw10
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Curation and family details
|Seed source:||KOGs (KOG2148)|
|Author:||KOGs, Finn RD, Coggill PC|
|Number in seed:||24|
|Number in full:||414|
|Average length of the domain:||511.00 aa|
|Average identity of full alignment:||21 %|
|Average coverage of the sequence by the domain:||63.19 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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