Summary: Preprotein translocase subunit Sec66
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Preprotein translocase subunit Sec66 Provide feedback
Members of this family of proteins are a component of the heterotetrameric Sec62/63 complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. Sec 66 is involved in SRP-independent post-translational translocation across the endoplasmic reticulum and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. Furthermore, Sec66 is also required for growth at elevated temperatures .
Feldheim D, Yoshimura K, Admon A, Schekman R; , Mol Biol Cell. 1993;4:931-939.: Structural and functional characterization of Sec66p, a new subunit of the polypeptide translocation apparatus in the yeast endoplasmic reticulum. PUBMED:8257795 EPMC:8257795
Kurihara T, Silver P; , Mol Biol Cell. 1993;4:919-930.: Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus. PUBMED:8257794 EPMC:8257794
Deshaies RJ, Sanders SL, Feldheim DA, Schekman R; , Nature. 1991;349:806-808.: Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex. PUBMED:2000150 EPMC:2000150
Panzner S, Dreier L, Hartmann E, Kostka S, Rapoport TA; , Cell. 1995;81:561-570.: Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p. PUBMED:7758110 EPMC:7758110
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR018624
Members of this family of proteins are a component of the heterotetrameric Sec62/63 complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. Sec 66 is involved in SRP-independent post-translational translocation across the endoplasmic reticulum and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. Furthermore, Sec66 is also required for growth at elevated temperatures [PUBMED:8257795, PUBMED:8257794, PUBMED:2000150, PUBMED:7758110].
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Curation and family details
|Seed source:||KOGs (KOG4699)|
|Author:||KOGs, Finn RD, Coggill PC, Sammut SJ|
|Number in seed:||61|
|Number in full:||338|
|Average length of the domain:||173.30 aa|
|Average identity of full alignment:||34 %|
|Average coverage of the sequence by the domain:||72.10 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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