Summary: Selenium binding protein
Selenium binding protein Provide feedback
Selenium is an important nutrient that needs to be regulated since lack of the nutrient leads to cell abnormalities and high concentrations are toxic. SeBP regulates the level of free selenium in the cell by sequestering the nutrient during transport. SeBP acts as a pentamer and delivers the selenium to the selenophosphate synthetase enzyme . Each subunit is composed of an alpha helix on top of a four stranded twisted ss sheet, stabilised by hydrogen bonds .
Suzuki M, Lee DY, Inyamah N, Stadtman TC, Tjandra N; , J Biol Chem 2008; [Epub ahead of print]: Solution NMR structure of selenium-binding protein from methanococcus vannielii. PUBMED:18650445 EPMC:18650445
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR021603
Selenium is an important nutrient which needs to be regulated since lack of the nutrient leads to cell abnormalities and high concentrations are toxic.SeBP regulates the level of free selenium in the cell by sequestering the nutrient during transport. SeBP acts as a pentamer and delivers the selenium to the selenophosphate synthetase enzyme [PUBMED:18650445]. Each subunit is composed of an alpha helix on top of a four stranded twisted ss sheet, stabilised by hydrogen bonds [PUBMED:18650445]. members of this entry are restricted to the archaeal Methanococcales.
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a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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This superfamily is characterised by chains that form pentamers. Family structures are beta/alpha-propellers with additional short beta-strands that promote oligomeric assembly. Family members appear to be heavy-metal binding proteins.
The clan contains the following 2 members:SeleniumBinding YbjQ_1
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||3|
|Number in full:||13|
|Average length of the domain:||83.00 aa|
|Average identity of full alignment:||52 %|
|Average coverage of the sequence by the domain:||98.99 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SeleniumBinding domain has been found. There are 5 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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