Summary: Sgf11 (transcriptional regulation protein)
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The Sgf11 family is a SAGA complex subunit in Saccharomyces cerevisiae. The SAGA complex is a multisubunit protein complex involved in transcriptional regulation. SAGA combines proteins involved in interactions with DNA-bound activators and TATA-binding protein (TBP), as well as enzymes for histone acetylation and deubiquitylation .
Ingvarsdottir K, Krogan NJ, Emre NC, Wyce A, Thompson NJ, Emili A, Hughes TR, Greenblatt JF, Berger SL; , Mol Cell Biol 2005;25:1162-1172.: H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex. PUBMED:15657441 EPMC:15657441
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013246
The Sgf11 (SAGA-associated factor 11) family is a SAGA complex subunit in Saccharomyces cerevisiae (Baker's yeast). The SAGA complex is a multisubunit protein complex involved in transcriptional regulation. SAGA combines proteins involved in interactions with DNA-bound activators and TATA-binding protein (TBP), as well as enzymes for histone acetylation and deubiquitylation [PUBMED:15657441].
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Superfamily of classical and closely related C2H2 or beta-beta-alpha zinc finger DNA-binding domains.
The clan contains the following 19 members:4F5 DUF3449 GAGA Sgf11 zf-AD zf-BED zf-C2H2 zf-C2H2_2 zf-C2H2_4 zf-C2H2_6 zf-C2H2_7 zf-C2H2_jaz zf-C2HC_2 zf-Di19 zf-H2C2_2 zf-H2C2_5 zf-met zf-met2 zf-U1
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Author:||Mistry J, Wood V|
|Number in seed:||33|
|Number in full:||238|
|Average length of the domain:||32.80 aa|
|Average identity of full alignment:||46 %|
|Average coverage of the sequence by the domain:||10.50 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Sgf11 domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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