Summary: Shikimate dehydrogenase substrate binding domain
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Shikimate dehydrogenase substrate binding domain Provide feedback
This domain is the substrate binding domain of shikimate dehydrogenase .
Singh S, Korolev S, Koroleva O, Zarembinski T, Collart F, Joachimiak A, Christendat D; , J Biol Chem 2005;280:17101-17108.: Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae. PUBMED:15735308 EPMC:15735308
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013708
This domain is the substrate binding domain of shikimate dehydrogenase [PUBMED:15735308]. Shikimate dehydrogenase catalyses the fourth step of the mycobacterial Shikimate pathway, which results in the biosynthesis of chorismate. Chorismate is a precursor of aromatic amino acids, naphthoquinones, menaquinones and mycobactins [PUBMED:18260104, PUBMED:12637497]. This pathway is an important target for antibacterial agents, especially against Mycobacterium tuberculosis, since it does not occur in mammals.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||shikimate 3-dehydrogenase (NADP+) activity (GO:0004764)|
|Biological process||oxidation-reduction process (GO:0055114)|
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Curation and family details
|Seed source:||Pfam-B_99 (release 18.0)|
|Number in seed:||40|
|Number in full:||6595|
|Average length of the domain:||81.30 aa|
|Average identity of full alignment:||34 %|
|Average coverage of the sequence by the domain:||25.44 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Shikimate_dh_N domain has been found. There are 89 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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