Summary: Wnt and FGF inhibitory regulator
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Wnt and FGF inhibitory regulator Provide feedback
Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.
Yamamoto A, Nagano T, Takehara S, Hibi M, Aizawa S;, Cell. 2005;120:223-235.: Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. PUBMED:15680328 EPMC:15680328
Internal database links
|SCOOP:||RSN1_TM LRRC37AB_C TMEM52 FAM163 TMEM154 FAM209 FAM104 ECSCR DUF4834 DUF5050|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR026910
Shisa is a tansmembrane, transcription factor-type protein that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface [PUBMED:15680320, PUBMED:18033675].
The Shisa family founding member, Xenopus Shisa, promotes head development by antagonising Wnt and FGF signaling [PUBMED:15680328]. Several vertebrate homologues have been identified with implicated roles in development, cancer and apoptosis [PUBMED:16773659, PUBMED:18954025, PUBMED:12135983]. Distantly related Shisa homologues have also been detected that possess an N-terminal domain with six conserved cysteines. These Shisa-like proteins include FAM159 and members from various bilaterian invertebrates and Porifera [PUBMED:22120523].
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Curation and family details
|Number in seed:||45|
|Number in full:||593|
|Average length of the domain:||148.10 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||55.96 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
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