Summary: Skp1 family, tetramerisation domain
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Skp1 family, tetramerisation domain Provide feedback
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR016073
SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex [PUBMED:10205047]. It was found to bind several F-box containing proteins (e.g., Cdc4, Skp2, cyclin F) and to be involved in the ubiquitin protein degradation pathway. A yeast homologue of SKP1 (P52286) was identified in the centromere bound kinetochore complex [PUBMED:8670864] and is also involved in the ubiquitin pathway [PUBMED:9390558]. In Dictyostelium discoideum (Slime mold) FP21 was shown to be glycosylated in the cytosol and has homology to SKP1 [PUBMED:7852383].
This entry represents a POZ domain with a core structure consisting of beta(2)/alpha(2)/beta(2)/alpha(2) in two layers, alpha/beta. This domain is found at the N-terminal of SKP1 proteins [PUBMED:11099048] as well as in subunit D of the centromere DNA-binding protein complex Cbf3 [PUBMED:12553912].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Biological process||ubiquitin-dependent protein catabolic process (GO:0006511)|
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The POZ domain is found in a variety of transcription factors. POZ domains are also found in the tetramerisation domain of voltage gated K+ channels. In general these domains mediate homo-oligomerisation.
The clan contains the following 5 members:BACK BTB BTB_2 DUF3342 Skp1_POZ
We make a range of alignments for each Pfam-A family:
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
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Curation and family details
|Seed source:||Bateman A|
|Author:||Bateman A, Griffiths-Jones SR|
|Number in seed:||17|
|Number in full:||1315|
|Average length of the domain:||61.60 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||39.07 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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There are 4 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Skp1_POZ domain has been found. There are 90 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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