Summary: Spc97 / Spc98 family
Spc97 / Spc98 family Provide feedback
The spindle pole body (SPB) functions as the microtubule-organising centre in yeast. Members of this family are spindle pole body (SBP) components such as Spc97 and Spc98 that form a complex with gamma-tubulin. This family of proteins includes the grip motif 1 and grip moti 2 . Members of this family all form components of the gamma-tubulin complex, GCP .
Gunawardane RN, Martin OC, Cao K, Zhang L, Dej K, Iwamatsu A, Zheng Y; , J Cell Biol. 2000;151:1513-1524.: Characterization and reconstitution of Drosophila gamma-tubulin ring complex subunits. PUBMED:11134079 EPMC:11134079
Kikuchi M, Nishima T;, Nihon Eiseigaku Zasshi. 1975;30:108.: [Correlation of concentrations of gamma aminolevulinic acid and creatinine in the urine (screening test for lead exposure by urinary spot samples)]. PUBMED:1169457 EPMC:1169457
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007259
Members of this family are spindle pole body (SBP) components such as Spc97, Spc98 and gamma-tubulin. The SPB functions as the microtubule-organising centre in yeast, with the microtubule cytoskeleton playing an essential role in chromosome segregation, cellular organisation and vesicle trafficking in eukaryotic cells. In most cells, the centrosome is the primary microtubule-organising centre that nucleates and organises microtubules. Gamma-tubulin localises to centrosomes and is required for microtubule nucleation. In Saccharomyces cerevisiae, gamma-tubulin forms a stable complex with Spc97 and Spc98 [PUBMED:11950928].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||microtubule organizing center (GO:0005815)|
|spindle pole (GO:0000922)|
|Biological process||microtubule cytoskeleton organization (GO:0000226)|
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This superfamily carries families of proteins all derived via gene-duplication events that act together in the gamma-tubulin complex. This complex is required for microtubule nucleation at the centrosome.
The clan contains the following 2 members:GCP5-Mod21 Spc97_Spc98
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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Curation and family details
|Seed source:||Pfam-B_3531 (release 7.3)|
|Number in seed:||94|
|Number in full:||3074|
|Average length of the domain:||543.00 aa|
|Average identity of full alignment:||16 %|
|Average coverage of the sequence by the domain:||64.65 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null --hand HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Spc97_Spc98 domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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