Summary: Tubulin binding cofactor C
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Tubulin binding cofactor C Provide feedback
Members of this family are involved in the folding pathway of tubulins and form a beta helix structure .
Kirik V, Mathur J, Grini PE, Klinkhammer I, Adler K, Bechtold N, Herzog M, Bonneville JM, Hulskamp M; , Curr Biol 2002;12:1519-1523.: Functional analysis of the tubulin-folding cofactor C in Arabidopsis thaliana. PUBMED:12225668 EPMC:12225668
Kuhnel K, Veltel S, Schlichting I, Wittinghofer A;, Structure. 2006;14:367-378.: Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. PUBMED:16472755 EPMC:16472755
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR012945
This domain is found in tubulin-binding cofactor C (or tubulin-specific chaperone C) (TBCC) and in protein XRP2. TBCC is a folding cofactor that participates in tubulin biogenesis along with the other tubulin folding cofactors A (TBCA), B (TBCB), E (TBCE) and D (TBCD), as well as the GTP-binding protein Arl2 [PUBMED:17184771, PUBMED:12225668]. XRP2 is a GTPase-activating protein (GAP) involved in intracellular trafficking [PUBMED:18376416].
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Curation and family details
|Seed source:||Pfam-B_4111 (release 16.0)|
|Number in seed:||46|
|Number in full:||1129|
|Average length of the domain:||115.80 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||26.75 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TBCC domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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