Summary: TLC ATP/ADP transporter
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TLC ATP/ADP transporter Provide feedback
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Tjaden J, Winkler HH, Schwoppe C, Van Der Laan M, Mohlmann T, Neuhaus HE; , J Bacteriol 1999;181:1196-1202.: Two nucleotide transport proteins in Chlamydia trachomatis, one for net nucleoside triphosphate uptake and the other for transport of energy. PUBMED:9973346 EPMC:9973346
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This tab holds annotation information from the InterPro database.
InterPro entry IPR004667
These proteins are members of the ATP:ADP Antiporter (AAA) family, which consists of nucleotide transporters that have 12 GES predicted transmembrane regions. One protein from Rickettsia prowazekii functions to take up ATP from the eukaryotic cell cytoplasm into the bacterium in exchange for ADP. Five AAA family paralogues are encoded within the genome of R. prowazekii. This organism transports UMP and GMP but not CMP, and it seems likely that one or more of the AAA family paralogues are responsible. The genome of Chlamydia trachomatis encodes two AAA family members, Npt1 and Npt2, which catalyse ATP/ADP exchange and GTP, CTP, ATP and UTP uptake probably employing a proton symport mechanism. Two homologous adenylate translocators of Arabidopsis thaliana are postulated to be localized to the intracellular plastid membrane where they function as ATP importers.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||integral to membrane (GO:0016021)|
|Molecular function||ATP binding (GO:0005524)|
|ATP:ADP antiporter activity (GO:0005471)|
|Biological process||transport (GO:0006810)|
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The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth . It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity . All permeases of the MFS possess either 12 or 14 transmembrane helices .
The clan contains the following 25 members:Acatn ATG22 BT1 CLN3 DUF1228 DUF791 Folate_carrier FPN1 FTR1 LacY_symp MFS_1 MFS_1_like MFS_2 MFS_3 MFS_Mycoplasma Nodulin-like Nuc_H_symport Nucleoside_tran OATP PTR2 PUCC Sugar_tr TLC TRI12 UNC-93
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Curation and family details
|Seed source:||Pfam-B_2261 (release 6.5)|
|Number in seed:||27|
|Number in full:||560|
|Average length of the domain:||424.20 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||84.80 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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