Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 730  species 0  interactions 920  sequences 9  architectures

Family: TPR_MLP1_2 (PF07926)

Summary: TPR/MLP1/MLP2-like protein

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

TPR/MLP1/MLP2-like protein Provide feedback

The sequences featured in this family are similar to a region of human TPR protein (P12270) and to yeast myosin-like proteins 1 (MLP1, Q02455) and 2 (MLP2, P40457). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores [1,2,3]. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments [1] and is implicated in nuclear protein import [2]. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerisation of kinase domains or by targeting these kinases to the nuclear pore complex [2]. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity [4].

Literature references

  1. Cordes VC, Reidenbach S, Rackwitz HR, Franke WW; , J Cell Biol 1997;136:515-529.: Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments. PUBMED:9024684 EPMC:9024684

  2. Byrd DA, Sweet DJ, Pante N, Konstantinov KN, Guan T, Saphire AC, Mitchell PJ, Cooper CS, Aebi U, Gerace L; , J Cell Biol 1994;127:1515-1526.: Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. PUBMED:7798308 EPMC:7798308

  3. Kosova B, Pante N, Rollenhagen C, Podtelejnikov A, Mann M, Aebi U, Hurt E; , J Biol Chem 2000;275:343-350.: Mlp2p, a component of nuclear pore attached intranuclear filaments, associates with nic96p. PUBMED:10617624 EPMC:10617624

  4. Hediger F, Dubrana K, Gasser SM; , J Struct Biol 2002;140:79-91.: Myosin-like proteins 1 and 2 are not required for silencing or telomere anchoring, but act in the Tel1 pathway of telomere length control. PUBMED:12490156 EPMC:12490156


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR012929

This domain is found in a number of proteins, including TPR protein (SWISSPROT) and yeast myosin-like protein 1 (MLP1, SWISSPROT). These proteins share a number of features; for example, they have coiled-coil regions and are associated with nuclear pores [PUBMED:9024684, PUBMED:7798308, PUBMED:10085285]. TPR is thought to be a component of nuclear pore complex- attached intranuclear filaments [PUBMED:9024684], and is implicated in nuclear protein import [PUBMED:7798308]. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerisation of kinase domains or by targeting these kinases to the nuclear pore complex [PUBMED:7798308]. Mlp1 acts as a docking platform for for heterogeneous nuclear ribonucleoproteins that are required for mRNA export [PUBMED:12531921].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(125)
Full
(920)
Representative proteomes UniProt
(1318)
NCBI
(1987)
Meta
(1)
RP15
(216)
RP35
(462)
RP55
(682)
RP75
(836)
Jalview View  View  View  View  View  View  View  View  View 
HTML View  View               
PP/heatmap 1 View               

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(125)
Full
(920)
Representative proteomes UniProt
(1318)
NCBI
(1987)
Meta
(1)
RP15
(216)
RP35
(462)
RP55
(682)
RP75
(836)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(125)
Full
(920)
Representative proteomes UniProt
(1318)
NCBI
(1987)
Meta
(1)
RP15
(216)
RP35
(462)
RP55
(682)
RP75
(836)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_9285 (release 14.0)
Previous IDs: none
Type: Coiled-coil
Sequence Ontology: SO:0001080
Author: Fenech M
Number in seed: 125
Number in full: 920
Average length of the domain: 127.80 aa
Average identity of full alignment: 28 %
Average coverage of the sequence by the domain: 6.43 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 32.9 32.9
Trusted cut-off 32.9 33.1
Noise cut-off 32.8 32.7
Model length: 129
Family (HMM) version: 12
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.