Summary: Thrombospondin C-terminal region
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Thrombospondin C-terminal region Provide feedback
This region is found at the C-terminus of thrombospondin and related proteins.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR008859
Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. They act as regulators of cell interactions in vertebrates. They are divided into two subfamilies, A and B, according to their overall molecular organisation. The subgroup A proteins TSP-1 and -2 contain an N-terminal domain, a VWFC domain, three TSP1 repeats, three EGF-like domains, TSP3 repeats and a C-terminal domain. They are assembled as trimer. The subgroup B thrombospondins, designated TSP-3, -4, and COMP (cartilage oligomeric matrix protein, also designated TSP-5) are distinct in that they contain unique N-terminal regions, lack the VWFC domain and TSP1 repeats, contain four copies of EGF-like domains, and are assembled as pentamers [PUBMED:11687483]. EGF, TSP3 repeats and the C-terminal domain are thus the hallmark of a thrombospondin.
The globular C-terminal domain is a beta sandwich of two curved antiparallel beta-sheets [PUBMED:15014436]. The fold is an elaboration of the jelly role topology, with strand B3-B7, B11 and B14-B15 forming the eight-stranded jelly roll motif. The function of the C-terminal domain is not yet known.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||extracellular region (GO:0005576)|
|Molecular function||calcium ion binding (GO:0005509)|
|Biological process||cell adhesion (GO:0007155)|
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Curation and family details
|Seed source:||Pfam-B_1875 (release 8.0)|
|Number in seed:||10|
|Number in full:||444|
|Average length of the domain:||188.30 aa|
|Average identity of full alignment:||65 %|
|Average coverage of the sequence by the domain:||21.57 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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There are 2 interactions for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TSP_C domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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