Summary: Tap, RNA-binding
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Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element .
Ho DN, Coburn GA, Kang Y, Cullen BR, Georgiadis MM; , Proc Natl Acad Sci U S A. 2002;99:1888-1893.: The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor. PUBMED:11854490 EPMC:11854490
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR015245
This domain adopts a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. It is mainly found in mRNA export factors, which mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element [PUBMED:11854490].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||nucleus (GO:0005634)|
|Molecular function||RNA binding (GO:0003723)|
|Biological process||mRNA export from nucleus (GO:0006406)|
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Curation and family details
|Number in seed:||12|
|Number in full:||238|
|Average length of the domain:||85.00 aa|
|Average identity of full alignment:||43 %|
|Average coverage of the sequence by the domain:||15.68 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Tap-RNA_bind domain has been found. There are 12 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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