Summary: Tash protein PEST motif
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Tash protein PEST motif Provide feedback
This motif is found in the Tash AT-hook proteins of Theileria annulata. These proteins are transported to the hosts nucleus and are likely to be involved in pathogenesis . It is also often found in conjunction with PF04385. It is suggested that they may be 'part of PEST motifs' (a signal for rapid proteolytic degradation) in  though this is not definite. This motif is also found in other T. annulata proteins, which have no other known domains in (unpublished data: C Yeats).
Swan DG, Stern R, McKellar S, Phillips K, Oura CA, Karagenc TI, Stadler L, Shiels BR; , J Cell Sci 2001;114:2747-2754.: Characterisation of a cluster of genes encoding Theileria annulata AT hook DNA-binding proteins and evidence for localisation to the host cell nucleus. PUBMED:11683409 EPMC:11683409
Shiels BR, McKellar S, Katzer F, Lyons K, Kinnaird J, Ward C, Wastling JM, Swan D; , Eukaryot Cell 2004;3:495-505.: A Theileria annulata DNA binding protein localized to the host cell nucleus alters the phenotype of a bovine macrophage cell line. PUBMED:15075278 EPMC:15075278
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR011695
The PEST motif is found in one or more copies in Tash AT-hook proteins from Theileria annulata. Tash proteins are transported to the host nucleus and are thought to be involved in pathogenesis [PUBMED:11683409]. The PEST motif is often found in conjunction with the (INTERPRO), whose function is unknown. These repeats may be part of the PEST motif (a signal for rapid proteolytic degradation) [PUBMED:15075278], though this is not proven. This motif is also found in other T. annulata proteins, which have no other known domains.
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Curation and family details
|Seed source:||Yeats C|
|Number in seed:||11|
|Number in full:||113|
|Average length of the domain:||18.70 aa|
|Average identity of full alignment:||62 %|
|Average coverage of the sequence by the domain:||4.55 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
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