Summary: TatD related DNase
TatD related DNase Provide feedback
This family of proteins are related to a large superfamily of metalloenzymes . TatD, a member of this family has been shown experimentally to be a DNase enzyme.
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T; , J Biol Chem 2000;275:16717-16722.: TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export. PUBMED:10747959 EPMC:10747959
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001130This family of proteins are related to a large superfamily of metalloenzymes [PUBMED:9144792]. TatD, a member of this family has been shown experimentally to be a DNase enzyme [PUBMED:10747959]. Allantoinase EC, N-isopropylammelide isopropyl amidohydrolase EC and the SCN1 protein from fission yeast belong to this family.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||endodeoxyribonuclease activity, producing 5'-phosphomonoesters (GO:0016888)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
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This family includes a large family of metal dependent amidohydrolase enzymes .
The clan contains the following 16 members:A_deaminase Amidohydro_1 Amidohydro_2 Amidohydro_3 Amidohydro_4 Amidohydro_5 DHOase DUF3604 Peptidase_M19 PHP PHP_C PTE RNase_P_p30 TatD_DNase Urease_alpha UxaC
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Pfam-B_1370 (release 3.0)|
|Number in seed:||98|
|Number in full:||8430|
|Average length of the domain:||252.30 aa|
|Average identity of full alignment:||29 %|
|Average coverage of the sequence by the domain:||93.02 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||16|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TatD_DNase domain has been found. There are 19 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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