Summary: Tenuivirus movement protein
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Tenuivirus movement protein Provide feedback
This family of ssRNA negative-strand crop plant tenuivirus proteins appears to combine PV2  NS2  NS3, and PV3 proteins. Plant viruses encode specific proteins known as movement proteins (MPs) to control their spread through plasmodesmata (PD) in walls between cells as well as from leaf to leaf via vascular-dependent transport. During this movement process, the virally encoded MPs interact with viral genomes for transport from the viral replication sites to the PDs in the walls of infected cells along the cytoskeleton and/or endoplasmic reticulum (ER) network. The virus is then thought to move through the PDs in the form of MP-associated ribonucleoprotein complexes or as virions . The NS3 protein appears to function as an RNA silencing suppressor .
Estabrook EM, Suyenaga K, Tsai JH, Falk BW; , Virus Genes 1996;12:239-247.: Maize stripe tenuivirus RNA2 transcripts in plant and insect hosts and analysis of pvc2, a protein similar to the Phlebovirus virion membrane glycoproteins. PUBMED:8883361 EPMC:8883361
Xiong R, Wu J, Zhou Y, Zhou X;, Virology. 2009;387:29-40.: Characterization and subcellular localization of an RNA silencing suppressor encoded by Rice stripe tenuivirus. PUBMED:19251298 EPMC:19251298
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007974
Plant viruses encode specific proteins known as movement proteins (MPs) to control their spread through plasmodesmata (PD) in walls between cells as well as from leaf to leaf via vascular-dependent transport. During this movement process, the virally encoded MPs interact with viral genomes for transport from the viral replication sites to the PDs in the walls of infected cells along the cytoskeleton and/or endoplasmic reticulum (ER) network. The virus is then thought to move through the PDs in the form of MP-associated ribonucleoprotein complexes or as virions [PUBMED:18818319]. The NS3 protein appears to function as an RNA silencing suppressor [PUBMED:19251298].
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Curation and family details
|Seed source:||Pfam-B_7740 (release 7.7)|
|Number in seed:||9|
|Number in full:||133|
|Average length of the domain:||172.50 aa|
|Average identity of full alignment:||48 %|
|Average coverage of the sequence by the domain:||84.62 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Tenui_NS3 domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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