Summary: Integral membrane protein TerC family
Integral membrane protein TerC family Provide feedback
This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance . Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.
Kormutakova R, Klucar L, Turna J; , Biometals 2000;13:135-139.: DNA sequence analysis of the tellurite-resistance determinant from clinical strain of Escherichia coli and identification of essential genes. PUBMED:11016400 EPMC:11016400
Burian J, Tu N, Kl'ucar L, Guller L, Lloyd-Jones G, Stuchlik S, Fejdi P, Siekel P, Turna J; , Folia Microbiol (Praha) 1998;43:589-599.: In vivo and in vitro cloning and phenotype characterization of tellurite resistance determinant conferred by plasmid pTE53 of a clinical isolate of Escherichia coli. PUBMED:10069007 EPMC:10069007
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR005496A family containining a number of integral membrane proteins is named after TerC protein. TerC has been implicated in resistance to tellurium, and may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of a group of clinical isolates for antibiotic and heavy metal ion resistance [PUBMED:10069007]. The determinant of the strain's tellurite resistance was located on a large conjugative plasmid, and analyses showed the genes terB, terC, terD and terE were essential for conservation of this resistance. Members of this family contain a number of conserved aspartates which may be involved in metal ion binding.
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|Cellular component||integral to membrane (GO:0016021)|
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Curation and family details
|Number in seed:||93|
|Number in full:||6495|
|Average length of the domain:||192.90 aa|
|Average identity of full alignment:||30 %|
|Average coverage of the sequence by the domain:||58.96 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
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