Summary: TfoX C-terminal domain
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TfoX C-terminal domain Provide feedback
TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes . This family corresponds to the C-terminal presumed domain of TfoX. The domain is found associated with PF00383 in Q9JZR1. It is also found as an isolated domain in some proteins suggesting this is an autonomous domain.
Zulty JJ, Barcak GJ; , Proc Natl Acad Sci U S A 1995;92:3616-3620.: Identification of a DNA transformation gene required for com101A+ expression and supertransformer phenotype in Haemophilus influenzae. PUBMED:7724607 EPMC:7724607
Williams PM, Bannister LA, Redfield RJ; , J Bacteriol 1994;176:6789-6794.: The Haemophilus influenzae sxy-1 mutation is in a newly identified gene essential for competence. PUBMED:7961436 EPMC:7961436
This tab holds annotation information from the InterPro database.
InterPro entry IPR007077
This domain is found in a number of bacterial proteins including the TfoX gene product of Haemophilus influenzae. TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes [PUBMED:7724607]. This family corresponds to the C-terminal presumed domain of TfoX. The domain is found in association with the N-terminal domain in some, but not all members of this group, suggesting this is an autonomous and functionally unrelated domain. For example it is found associated with SWISSPROT in INTERPRO.
- the number of sequences which exhibit this architecture
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Gladomain, followed by two consecutive
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This superfamily includes Helix-hairpin-helix DNA-binding domains.
The clan contains the following 20 members:Cdd1 DNA_pol_lambd_f DUF3173 DUF4332 DUF655 HHH HhH-GPD HHH_2 HHH_3 HHH_4 HHH_5 HHH_6 HHH_7 HHH_8 IMS_HHH PsbU RNA_pol_A_CTD T2SSK TfoX_C Transposase_20
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the UniProtKB sequence database using the family HMM
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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Curation and family details
|Number in seed:||37|
|Number in full:||210|
|Average length of the domain:||79.70 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||54.18 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.