Summary: Transcription- and export-related complex subunit
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Transcription- and export-related complex subunit Provide feedback
The THO/TREX complex is the transcription- and export-related complex associated with spliceosomes that preferentially deal with spliced mRNAs as opposed to unspliced mRNAs. Thoc2 plays a role in RNA polymerase II (RNA pol II)-dependent transcription and is required for the stability of DNA repeats [1]. In humans, the TRE complex is comprised of the exon-junction-associated proteins Aly/REF and UAP56 together with the THO proteins THOC1 (hHpr1/p84), Thoc2 (hRlr1), THOC3 (hTex1), THOC5 (fSAP79), THOC6 (fSAP35), and THOC7 (fSAP24). Although much evidence indicates that the function of the TREX complex as an adaptor between the mRNA and components of the export machinery is conserved among eukaryotes, in Drosophila the majority of mRNAs can be exported from the nucleus independently of the THO complex [2].
Literature references
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Piruat JI, Aguilera A; , EMBO J. 1998;17:4859-4872.: A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. PUBMED:9707445 EPMC:9707445
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Merz C, Urlaub H, Will CL, Luhrmann R; , RNA. 2007;13:116-128.: Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment. PUBMED:17095540 EPMC:17095540
This tab holds annotation information from the InterPro database.
InterPro entry IPR021726
The THO/TREX complex is the transcription- and export-related complex associated with spliceosomes that preferentially deal with spliced mRNAs as opposed to unspliced mRNAs. Thoc2 plays a role in RNA polymerase II (RNA pol II)-dependent transcription and is required for the stability of DNA repeats [PUBMED:9707445]. In humans, the TRE complex is comprised of the exon-junction-associated proteins Aly/REF and UAP56 together with the THO proteins THOC1 (hHpr1/p84), Thoc2 (hRlr1), THOC3 (hTex1), THOC5 (fSAP79), THOC6 (fSAP35), and THOC7 (fSAP24). Although much evidence indicates that the function of the TREX complex as an adaptor between the mRNA and components of the export machinery is conserved among eukaryotes, in Drosophila the majority of mRNAs can be exported from the nucleus independently of the THO complex [PUBMED:17095540].
This entry represents a conserved domain found towards the N terminus of these proteins.
Domain organisation
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Seed (94) |
Full (1503) |
Representative proteomes | UniProt (2494) |
NCBI (3381) |
Meta (3) |
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RP15 (247) |
RP35 (635) |
RP55 (1090) |
RP75 (1548) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (94) |
Full (1503) |
Representative proteomes | UniProt (2494) |
NCBI (3381) |
Meta (3) |
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RP15 (247) |
RP35 (635) |
RP55 (1090) |
RP75 (1548) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
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Curation
Seed source: | Pfam-B_819 (release 23.0) |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
Mistry J |
Number in seed: | 94 |
Number in full: | 1503 |
Average length of the domain: | 75.30 aa |
Average identity of full alignment: | 44 % |
Average coverage of the sequence by the domain: | 4.22 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 76 | ||||||||||||
Family (HMM) version: | 9 | ||||||||||||
Download: | download the raw HMM for this family |
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