Summary: Trehalose utilisation
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Trehalose utilisation Provide feedback
This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose . The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium .
Jensen JB, Peters NK, Bhuvaneswari TV; , J Bacteriol. 2002;184:2978-2986.: Redundancy in periplasmic binding protein-dependent transport systems for trehalose, sucrose, and maltose in Sinorhizobium meliloti. PUBMED:12003938 EPMC:12003938
Ampomah OY, Jensen JB, Bhuvaneswari TV; , New Phytol. 2008;179:495-504.: Lack of trehalose catabolism in Sinorhizobium species increases their nodulation competitiveness on certain host genotypes. PUBMED:18422894 EPMC:18422894
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This tab holds annotation information from the InterPro database.
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Most members of this clan are glutaminase enzymes. This superfamily is shown to be related in . The clan also contains the DJ-1/PfpI family that includes the peptidase PfpI that has a catalytic Cys-His-Glu triad that differs from the class I GAT Cys-His-Glu triad.
The clan contains the following 13 members:BPL_N DJ-1_PfpI DUF1355 DUF4066 GATase GATase_3 GATase_5 Glyco_hydro_42M HTS Peptidase_C26 Peptidase_S51 SNO ThuA
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Curation and family details
|Seed source:||Pfam-B_11803 (release 9.0)|
|Number in seed:||91|
|Number in full:||1197|
|Average length of the domain:||219.50 aa|
|Average identity of full alignment:||23 %|
|Average coverage of the sequence by the domain:||52.37 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null --hand HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ThuA domain has been found. There are 10 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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