Summary: Outer membrane protein transport protein (OMPP1/FadL/TodX)
This is the Wikipedia entry entitled "FadL outer membrane protein transport family". More...
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FadL outer membrane protein transport family Edit Wikipedia article
|Outer membrane transport proteins (OMPP1/FadL/TodX)|
Structure of the bacterial fatty acid transporter FadL.
Outer membrane transport proteins (OMPP1/FadL/TodX) family includes several proteins that are involved in toluene catabolism and degradation of aromatic hydrocarbons. This family also includes protein FadL involved in translocation of long-chain fatty acids across the outer membrane. It is also a receptor for the bacteriophage T2.
- Wang, Y.; Rawlings, M.; Gibson, D. T.; Labbé, D.; Bergeron, H.; Brousseau, R.; Lau, P. C. (1995). "Identification of a membrane protein and a truncated LysR-type regulator associated with the toluene degradation pathway in Pseudomonas putida F1". Molecular & general genetics : MGG. 246 (5): 570–579. doi:10.1007/bf00298963. PMID 7535376.
- Kahng, H. Y.; Byrne, A. M.; Olsen, R. H.; Kukor, J. J. (2000). "Characterization and role of tbuX in utilization of toluene by Ralstonia pickettii PKO1". Journal of Bacteriology. 182 (5): 1232–1242. doi:10.1128/jb.182.5.1232-1242.2000. PMC . PMID 10671442.
- Eaton, R. W. (1997). "P-Cymene catabolic pathway in Pseudomonas putida F1: Cloning and characterization of DNA encoding conversion of p-cymene to p-cumate". Journal of Bacteriology. 179 (10): 3171–3180. PMC . PMID 9150211.
Outer membrane protein transport protein (OMPP1/FadL/TodX) Provide feedback
This family includes TodX from Pseudomonas putida F1 Q51971 and TbuX from Ralstonia pickettii PKO1 Q9RBW8. These are membrane proteins of uncertain function that are involved in toluene catabolism. Related proteins involved in the degradation of similar aromatic hydrocarbons are also in this family, such as CymD O33458. This family also includes FadL involved in translocation of long-chain fatty acids across the outer membrane. It is also a receptor for the bacteriophage T2.
Wang Y, Rawlings M, Gibson DT, Labbe D, Bergeron H, Brousseau R, Lau PC; , Mol Gen Genet 1995;246:570-579.: Identification of a membrane protein and a truncated LysR-type regulator associated with the toluene degradation pathway in Pseudomonas putida F1. PUBMED:7535376 EPMC:7535376
Eaton RW; , J Bacteriol 1997;179:3171-3180.: p-Cymene catabolic pathway in Pseudomonas putida F1: cloning and characterization of DNA encoding conversion of p-cymene to p-cumate. PUBMED:9150211 EPMC:9150211
Internal database links
|SCOOP:||Autotransporter BBP2 DUF2490 MtrB_PioB OMP_b-brl OmpA_membrane Porin_2 Porin_4 TonB_dep_Rec UPF0164|
|Similarity to PfamA using HHSearch:||DUF2490|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR005017
This family includes TodX from Pseudomonas putida (strain F1/ATCC 700007) SWISSPROT [PUBMED:7535376, PUBMED:9150211] and TbuX from Burkholderia pickettii (Ralstonia pickettii) (Pseudomonas pickettii) PKO1 SWISSPROT [PUBMED:10671442]. These are membrane proteins of uncertain function that are involved in toluene catabolism. Related proteins involved in the degradation of similar aromatic hydrocarbons are also in this family, such as CymD SWISSPROT. This family also includes FadL involved in translocation of long-chain fatty acids across the outer membrane. It is also a receptor for the bacteriophage T2.
- the number of sequences which exhibit this architecture
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This example describes an architecture with one
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This clan gathers together a large set of beta barrel membrane proteins.Although these proteins have different numbers of beta strands in the barrel they have significant sequence similarity between families.
The clan contains the following 89 members:Ail_Lom Alginate_exp Autotransporter Bac_surface_Ag BBP2 BBP2_2 BBP7 BCSC_C Campylo_MOMP Caps_assemb_Wzi Channel_Tsx Chlam_OMP CopB CymA DUF2219 DUF2490 DUF2715 DUF2860 DUF3078 DUF3138 DUF3187 DUF3373 DUF3573 DUF3575 DUF4421 DUF4595 DUF481 DUF5020 DUF560 Gcw_chp HP_OMP HP_OMP_2 HpuA IAT_beta KdgM LamB Legionella_OMP Lipoprot_C MDM10 MipA MOSP_C MSP MtrB_PioB Omp_AT OMP_b-brl OMP_b-brl_2 OMP_b-brl_3 OmpA_like OmpA_membrane Omptin OmpW Opacity OpcA OprB OprD OprF OstA_C PagL PagP Phenol_MetA_deg PLA1 Pom Porin_1 Porin_10 Porin_2 Porin_3 Porin_4 Porin_5 Porin_6 Porin_7 Porin_8 Porin_O_P Porin_OmpG Porin_OmpG_1_2 Porin_OmpL1 PorP_SprF ShlB Surface_Ag_2 TbpB_B_D Toluene_X TonB_dep_Rec TraF_2 TSA UPF0164 Usher Usher_TcfC YadA_anchor YfaZ YjbH
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_3708 (release 6.5)|
|Number in seed:||12|
|Number in full:||1978|
|Average length of the domain:||379.30 aa|
|Average identity of full alignment:||18 %|
|Average coverage of the sequence by the domain:||89.82 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Toluene_X domain has been found. There are 33 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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