Summary: Spider insecticidal peptide
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This family consists of insecticidal peptides isolated from venom of spiders of Aptostichus schlingeri and Calisoga sp. Nine insecticidal peptides were isolated from the venom of the Aptostichus schlingeri spider and seven of these toxins cause flaccid paralysis to insect larvae within 10 min of injection. However, all nine peptides were lethal within 24 hours . The structure of Aps III was solved and shown to be an atypical knottin peptide with four disulphide bridges .
Skinner WS, Dennis PA, Li JP, Quistad GB; , Toxicon 1992;30:1043-1050.: Identification of insecticidal peptides from venom of the trap-door spider, Aptostichus schlingeri (Ctenizidae). PUBMED:1440641 EPMC:1440641
Bende NS, Kang E, Herzig V, Bosmans F, Nicholson GM, Mobli M, King GF;, Biochem Pharmacol. 2013; [Epub ahead of print]: The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels. PUBMED:23473802 EPMC:23473802
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR012626
This family consists of insecticidal peptides isolated from venom of spiders of Aptostichus schlingeri (Trap-door spider) and Calisoga sp. Nine insecticidal peptides were isolated from the venom of the A. schlinger spider and seven of these toxins cause flaccid paralysis to insect larvae within 10 min of injection. However, all nine peptides were lethal within 24 hours [PUBMED:1440641].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||extracellular region (GO:0005576)|
|Biological process||pathogenesis (GO:0009405)|
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This clan contains a set of related small protein toxins and what appears to be the functionally distinct Albumin I domain. All members of this clan have a knottin-like fold. Additional information about this clan may be found from .
The clan contains the following 22 members:Agouti Albumin_I Albumin_I_a Chi-conotoxin Conotoxin Mu-conotoxin Omega-toxin Tachystatin_A Tachystatin_B Toxin_11 Toxin_12 Toxin_16 Toxin_18 Toxin_21 Toxin_22 Toxin_23 Toxin_24 Toxin_27 Toxin_30 Toxin_7 Toxin_9 UPF0506
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Curation and family details
|Seed source:||Short protein clustering|
|Previous IDs:||Toxin_21; Toxin_21_;|
|Author:||Lee SC, Bateman A|
|Number in seed:||2|
|Number in full:||5|
|Average length of the domain:||38.20 aa|
|Average identity of full alignment:||57 %|
|Average coverage of the sequence by the domain:||69.96 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Toxin_21 domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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