Summary: Magi 5 toxic peptide family
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This family consists of toxic peptides (Magi 5) found in the venom of the Hexathelidae spider. Magi 5 is the first spider toxin with binding affinity to site 4 of a mammalian sodium channel and the toxin has an insecticidal effect on larvae, causing paralysis when injected into the larvae .
Corzo G, Gilles N, Satake H, Villegas E, Dai L, Nakajima T, Haupt J; , FEBS Lett 2003;547:43-50.: Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel. PUBMED:12860384 EPMC:12860384
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR012628
This family consists of toxic peptides (Magi 5) found in the venom of the Hexathelidae spider. Magi 5 is the first spider toxin with binding affinity to site 4 of a mammalian sodium channel and the toxin has an insecticidal effect on larvae, causing paralysis when injected into the larvae.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||extracellular region (GO:0005576)|
|Molecular function||sodium channel inhibitor activity (GO:0019871)|
|Biological process||pathogenesis (GO:0009405)|
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This clan contains a set of related small protein toxins and what appears to be the functionally distinct Albumin I domain. All members of this clan have a knottin-like fold. Additional information about this clan may be found from .
The clan contains the following 22 members:Agouti Albumin_I Albumin_I_a Chi-conotoxin Conotoxin Mu-conotoxin Omega-toxin Tachystatin_A Tachystatin_B Toxin_11 Toxin_12 Toxin_16 Toxin_18 Toxin_21 Toxin_22 Toxin_23 Toxin_24 Toxin_27 Toxin_30 Toxin_7 Toxin_9 UPF0506
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Short protein clustering|
|Previous IDs:||Toxin_23; Toxin_23_;|
|Number in seed:||5|
|Number in full:||8|
|Average length of the domain:||29.20 aa|
|Average identity of full alignment:||50 %|
|Average coverage of the sequence by the domain:||36.68 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Toxin_23 domain has been found. There are 3 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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